O-TOLUIDINE-D3 (METHYL-D3)

Base Information

• Chemical Name: O-TOLUIDINE-D3 (METHYL-D3)
• CAS No.: 151985-13-6
• Molecular Formula: C₇H₉N
• Molecular Weight: 116.084
• Mol file: 151985-13-6.mol

Synonyms:O-TOLUIDINE-D3 (METHYL-D3)

Chemical Property of O-TOLUIDINE-D3 (METHYL-D3)

Chemical Property:

• PSA: 26.02000
• LogP: 2.15840

Purity/Quality:

99% ^*data from raw suppliers

o-Toluidine-d3(methyl-d3) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: o-Toluidine-d3 (methyl-d3) can be used to treat diseases.

Technology Process of O-TOLUIDINE-D3 (METHYL-D3)

There total 10 articles about O-TOLUIDINE-D3 (METHYL-D3) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

o-toluidine (95-53-4) → C7H3(2)H6N (1564263-99-5,151985-13-6)

Guidance literature:

With palladium on carbon; hydrogen; water-d2; at 180 ℃; for 24h; Sealed tube;

DOI:10.1039/c3ob42196a

Reference yield: 82.0%

o-toluidine (95-53-4) → 2-[2H9]toluidine (194423-47-7,151985-13-6)

Guidance literature:

With deuteriated sodium hydroxide; water-d2; at 400 ℃; for 12h;

DOI:10.1002/(SICI)1099-1344(199708)39:8<625::AID-JLCR15>3.0.CO;2-X

Reference yield: 49.8%

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → 2-methyl-<2H3>-aniline (151985-13-6)

Guidance literature:

With aluminum (III) chloride; lithium aluminium deuteride; In diethyl ether; at 0 - 20 ℃; for 12h; Reflux;

DOI:10.1021/acs.organomet.5b00385

upstream raw materials:

o-toluidine

2-carbomethoxyaniline

tert-butyl phenylcarbamate

anthranilic acid

Refernces

• 1、 Vidal, Xandro,Mascare?as, José Luis,Gulías, Moisés. "Assembly of Tetrahydroquinolines and 2-Benzazepines by Pd-Catalyzed Cycloadditions Involving the Activation of C(sp3)-H Bonds". supporting information. p. 5323 - 5328. Retrieved 2021/07/21.
• 2、 Lindley, Brian M.,Wolczanski, Peter T.,Cundari, Thomas R.,Lobkovsky, Emil B.. "First-Row Transition Metal and Lithium Pyridine-ene-amide Complexes Exhibiting N- and C-Isomers and Ligand-Based Activation of Benzylic C-H Bonds". supporting information. p. 4656 - 4668. Retrieved 2015/10/28.