7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(5-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Base Information

• Chemical Name: 7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(5-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide
• CAS No.: 497850-01-8
• Molecular Formula: C₃₈H₃₈F₃N₃O₆
• Molecular Weight: 689.731

Synonyms:7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(5-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Chemical Property of 7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(5-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Chemical Property:

Purity/Quality:

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Technology Process of 7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(5-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

There total 8 articles about 7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(5-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(5-methylpyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide (497850-00-7) → 7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(5-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide (497850-01-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃;

DOI:10.1248/cpb.52.818

Reference yield:

2-Bromo-5-methylpyridine (3510-66-5) → 7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(5-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide (497850-01-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 69 percent / sodium 4-methylbenzenesulfinate; NaH / tetrahydrofuran / Heating

2.1: 57 percent / K₂CO₃; O₂ / dimethylsulfoxide; H₂O / 20 °C

3.1: NaN₃ / dimethylsulfoxide / 90 °C

4.1: LiAlH₄ / tetrahydrofuran / 20 °C

5.1: benzotriazol-1-ol; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / dimethylformamide / 1.5 h / 20 °C

5.2: 75 percent / Et₃N / dimethylformamide / 20 °C

6.1: 79 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / 20 °C

With lithium aluminium tetrahydride; sodium azide; oxygen; sodium hydride; potassium carbonate; benzotriazol-1-ol; sodium 4-methylbenzenesulfinate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1248/cpb.52.818

Reference yield:

4-fluorophenylacetonitrile (459-22-3) → 7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(5-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide (497850-01-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 69 percent / sodium 4-methylbenzenesulfinate; NaH / tetrahydrofuran / Heating

2.1: 57 percent / K₂CO₃; O₂ / dimethylsulfoxide; H₂O / 20 °C

3.1: NaN₃ / dimethylsulfoxide / 90 °C

4.1: LiAlH₄ / tetrahydrofuran / 20 °C

5.1: benzotriazol-1-ol; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / dimethylformamide / 1.5 h / 20 °C

5.2: 75 percent / Et₃N / dimethylformamide / 20 °C

6.1: 79 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / 20 °C

With lithium aluminium tetrahydride; sodium azide; oxygen; sodium hydride; potassium carbonate; benzotriazol-1-ol; sodium 4-methylbenzenesulfinate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1248/cpb.52.818

upstream raw materials:

7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(5-methylpyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

2-Bromo-5-methylpyridine

4-fluorophenylacetonitrile

2-(4-fluorobenzoyl)-5-methylpyridine

Downstream raw materials:

7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(5-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide

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