(2S,3S)-3-Fluoromethyl-2-formylamino-3-hydroxy-4-((S)-toluene-4-sulfinyl)-butyric acid methyl ester

Base Information

Chemical Name:(2S,3S)-3-Fluoromethyl-2-formylamino-3-hydroxy-4-((S)-toluene-4-sulfinyl)-butyric acid methyl ester
CAS No.:185522-99-0
Molecular Formula:C₁₄H₁₈FNO₅S
Molecular Weight:331.365
Hs Code.:

Synonyms:(2S,3S)-3-Fluoromethyl-2-formylamino-3-hydroxy-4-((S)-toluene-4-sulfinyl)-butyric acid methyl ester

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Chemical Property of (2S,3S)-3-Fluoromethyl-2-formylamino-3-hydroxy-4-((S)-toluene-4-sulfinyl)-butyric acid methyl ester

Chemical Property:

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Technology Process of (2S,3S)-3-Fluoromethyl-2-formylamino-3-hydroxy-4-((S)-toluene-4-sulfinyl)-butyric acid methyl ester

There total 1 articles about (2S,3S)-3-Fluoromethyl-2-formylamino-3-hydroxy-4-((S)-toluene-4-sulfinyl)-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 185522-98-9
(4S,5S)-5-Fluoromethyl-5-((S)-toluene-4-sulfinylmethyl)-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

: 185522-99-0
(2S,3S)-3-Fluoromethyl-2-formylamino-3-hydroxy-4-((S)-toluene-4-sulfinyl)-butyric acid methyl ester

Guidance literature:: With water; In chloroform; Yield given; Ambient temperature;
DOI:10.1039/cc9960002569

Reference yield:

: 185522-99-0
(2S,3S)-3-Fluoromethyl-2-formylamino-3-hydroxy-4-((S)-toluene-4-sulfinyl)-butyric acid methyl ester

: 185523-00-6
(2S,3S)-3-Fluoromethyl-2-formylamino-3-hydroxy-4-p-tolylsulfanyl-butyric acid methyl ester

Guidance literature:: With trifluoroacetic anhydride; sodium iodide; In acetone; at -40 ℃;
DOI:10.1039/cc9960002569

Reference yield:

: 185522-99-0
(2S,3S)-3-Fluoromethyl-2-formylamino-3-hydroxy-4-((S)-toluene-4-sulfinyl)-butyric acid methyl ester

: 1363368-19-7
4-(4-(4-aminophenyl)buta-1,3-diynyl)-N-((2S,3S)-4-fluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yI)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium iodide; trifluoroacetic anhydride / acetone / 0.28 h / -10 °C / Inert atmosphere

2.1: water; sodium phosphinate hydrate / Raney Ni / methanol / 14 h / 20 °C / pH 5.2 / Inert atmosphere; Aqueous acetate buffer

3.1: hydrogenchloride / methanol / 14 h / 20 °C

3.2: pH 10

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere

5.1: hydroxylamine hydrochloride; sodium methylate; methanol / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; methanol; sodium phosphinate hydrate; hydroxylamine hydrochloride; water; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; sodium iodide; Raney Ni; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone;