(S)-2-[(2R,5S)-5-((1S,2S)-2-Hydroxy-1-methyl-pentyl)-tetrahydro-furan-2-yl]-propionic acid benzyl ester

Base Information

Chemical Name:(S)-2-[(2R,5S)-5-((1S,2S)-2-Hydroxy-1-methyl-pentyl)-tetrahydro-furan-2-yl]-propionic acid benzyl ester
CAS No.:870452-47-4
Molecular Formula:C₂₀H₃₀O₄
Molecular Weight:334.456
Hs Code.:

Synonyms:(S)-2-[(2R,5S)-5-((1S,2S)-2-Hydroxy-1-methyl-pentyl)-tetrahydro-furan-2-yl]-propionic acid benzyl ester

Suppliers and Price of (S)-2-[(2R,5S)-5-((1S,2S)-2-Hydroxy-1-methyl-pentyl)-tetrahydro-furan-2-yl]-propionic acid benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-[(2R,5S)-5-((1S,2S)-2-Hydroxy-1-methyl-pentyl)-tetrahydro-furan-2-yl]-propionic acid benzyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-2-[(2R,5S)-5-((1S,2S)-2-Hydroxy-1-methyl-pentyl)-tetrahydro-furan-2-yl]-propionic acid benzyl ester

There total 5 articles about (S)-2-[(2R,5S)-5-((1S,2S)-2-Hydroxy-1-methyl-pentyl)-tetrahydro-furan-2-yl]-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 870452-54-3,817166-32-8
(1S,2S,5S,6R,7R)-2,6-Dimethyl-5-propyl-4,10-dioxa-bicyclo[5.2.1]decan-3-one

: 100-51-6,185532-71-2
benzyl alcohol

: 870452-47-4
(S)-2-[(2R,5S)-5-((1S,2S)-2-Hydroxy-1-methyl-pentyl)-tetrahydro-furan-2-yl]-propionic acid benzyl ester

Guidance literature:: With lithium benzyloxide; In tetrahydrofuran; at 20 ℃;
DOI:10.1002/anie.200501511

Reference yield:

: 4,6-dimethyl-1,1-dioxo-3-propyl-3,4,6,7,8,8a-hexahydro-1H-1λ⁶-benzo[c][1,2]oxathiin-7-ol

: 870452-47-4
(S)-2-[(2R,5S)-5-((1S,2S)-2-Hydroxy-1-methyl-pentyl)-tetrahydro-furan-2-yl]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: ozone; NaHCO₃ / CH₂Cl₂ / -78 °C

1.2: 87 percent / acetic anhydride; pyridine / CH₂Cl₂ / Heating

2.1: 79 percent / BF₃*Et₂O / CH₂Cl₂ / 20 °C

3.1: 59 percent / H₂ / Raney Ni / ethanol / 20 °C / 37503 Torr

4.1: 100 percent / sodium hydroxide / 20 °C

5.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / tetrahydrofuran / 20 °C

5.2: 65 percent / 4-(N,N-dimethylamino)pyridine / toluene / Heating

6.1: 59 percent / PhCH₂OLi / tetrahydrofuran / 20 °C

With sodium hydroxide; 2,4,6-trichlorobenzoyl chloride; boron trifluoride diethyl etherate; lithium benzyloxide; hydrogen; sodium hydrogencarbonate; ozone; triethylamine; nickel; In tetrahydrofuran; ethanol; dichloromethane; 5.1: Yamaguchi lactonization;
DOI:10.1002/anie.200501511

Reference yield:

: 870452-53-2
(R)-2-((2R,6S,7S)-7-Methyl-4,4-dioxo-7a-phenylsulfanyl-6-propyl-hexahydro-1,5-dioxa-4λ⁶-thia-inden-2-yl)-propionic acid methyl ester

: 870452-47-4
(S)-2-[(2R,5S)-5-((1S,2S)-2-Hydroxy-1-methyl-pentyl)-tetrahydro-furan-2-yl]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 59 percent / H₂ / Raney Ni / ethanol / 20 °C / 37503 Torr

2.1: 100 percent / sodium hydroxide / 20 °C

3.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / tetrahydrofuran / 20 °C

3.2: 65 percent / 4-(N,N-dimethylamino)pyridine / toluene / Heating

4.1: 59 percent / PhCH₂OLi / tetrahydrofuran / 20 °C

With sodium hydroxide; 2,4,6-trichlorobenzoyl chloride; lithium benzyloxide; hydrogen; triethylamine; nickel; In tetrahydrofuran; ethanol; 3.1: Yamaguchi lactonization;
DOI:10.1002/anie.200501511