4-(2,4-difluorophenyl)-2-(2-chlorophenyl)-5-(4-methylthiophenyl)thiazole

Base Information

Chemical Name:4-(2,4-difluorophenyl)-2-(2-chlorophenyl)-5-(4-methylthiophenyl)thiazole
CAS No.:177560-83-7
Molecular Formula:C₂₂H₁₄ClF₂NS₂
Molecular Weight:429.942
Hs Code.:

Synonyms:4-(2,4-difluorophenyl)-2-(2-chlorophenyl)-5-(4-methylthiophenyl)thiazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2,4-difluorophenyl)-2-(2-chlorophenyl)-5-(4-methylthiophenyl)thiazole

Chemical Property:

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Technology Process of 4-(2,4-difluorophenyl)-2-(2-chlorophenyl)-5-(4-methylthiophenyl)thiazole

There total 3 articles about 4-(2,4-difluorophenyl)-2-(2-chlorophenyl)-5-(4-methylthiophenyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873-32-5
2-Chlorobenzonitrile

: 177560-83-7
4-(2,4-difluorophenyl)-2-(2-chlorophenyl)-5-(4-methylthiophenyl)thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: H₂S, Et₃N, pyridine

2: acetonitrile / Heating

With pyridine; hydrogen sulfide; triethylamine; In acetonitrile;
DOI:10.1016/S0960-894X(99)00158-4

Reference yield:

: 1-(2,5-difluoro-phenyl)-2-(4-methylsulfanyl-phenyl)-ethanone

: 177560-83-7
4-(2,4-difluorophenyl)-2-(2-chlorophenyl)-5-(4-methylthiophenyl)thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: Br₂, HBr, AcOH

2: acetonitrile / Heating

With hydrogen bromide; bromine; acetic acid; In acetonitrile;
DOI:10.1016/S0960-894X(99)00158-4