23-tert-butyl-5,11,17-trinitro-25-(p-nitrobenzenesulfonyloxy)-26,27,28-tripropoxycalix[4]arene

Base Information

• Chemical Name: 23-tert-butyl-5,11,17-trinitro-25-(p-nitrobenzenesulfonyloxy)-26,27,28-tripropoxycalix[4]arene
• CAS No.: 1378022-42-4
• Molecular Formula: C₄₇H₅₀N₄O₁₄S
• Molecular Weight: 926.998
• Mol file: 1378022-42-4.mol

Synonyms:23-tert-butyl-5,11,17-trinitro-25-(p-nitrobenzenesulfonyloxy)-26,27,28-tripropoxycalix[4]arene

Chemical Property of 23-tert-butyl-5,11,17-trinitro-25-(p-nitrobenzenesulfonyloxy)-26,27,28-tripropoxycalix[4]arene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 23-tert-butyl-5,11,17-trinitro-25-(p-nitrobenzenesulfonyloxy)-26,27,28-tripropoxycalix[4]arene

There total 3 articles about 23-tert-butyl-5,11,17-trinitro-25-(p-nitrobenzenesulfonyloxy)-26,27,28-tripropoxycalix[4]arene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5,11,17,23-tetra-tert-butyl-25-(p-nitrobenzenesulfonyloxy)-26,27,28-tripropoxycalix[4]arene (1378022-39-9) → 23-tert-butyl-5,11,17-trinitro-25-(p-nitrobenzenesulfonyloxy)-26,27,28-tripropoxycalix[4]arene (1378022-42-4)

Guidance literature:

With nitric acid; acetic acid; In dichloromethane; at 0 ℃; regioselective reaction;

DOI:10.1016/j.tet.2012.03.102

Reference yield:

5,11,17,23-tetra-t-butyl-25,26,27,28-tetrahydroxycalix-4-arene (157432-87-6,288302-11-4,288302-12-5,60705-62-6) → 23-tert-butyl-5,11,17-trinitro-25-(p-nitrobenzenesulfonyloxy)-26,27,28-tripropoxycalix[4]arene (1378022-42-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: barium(II) hydroxide; barium(II) oxide / N,N-dimethyl-formamide

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 120 h / 20 °C

3.1: nitric acid; acetic acid / dichloromethane / 0 °C

With nitric acid; sodium hydride; acetic acid; barium(II) hydroxide; barium(II) oxide; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1016/j.tet.2012.03.102

Reference yield:

tris(propoxy)-4-tert-butylcalix[4]arene (133301-64-1,133813-63-5,133867-68-2,133963-48-1) → 23-tert-butyl-5,11,17-trinitro-25-(p-nitrobenzenesulfonyloxy)-26,27,28-tripropoxycalix[4]arene (1378022-42-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 120 h / 20 °C

2.1: nitric acid; acetic acid / dichloromethane / 0 °C

With nitric acid; sodium hydride; acetic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1016/j.tet.2012.03.102

upstream raw materials:

5,11,17,23-tetra-tert-butyl-25-(p-nitrobenzenesulfonyloxy)-26,27,28-tripropoxycalix[4]arene

5,11,17,23-tetra-t-butyl-25,26,27,28-tetrahydroxycalix-4-arene

tris(propoxy)-4-tert-butylcalix[4]arene

Downstream raw materials:

5-tert-butyl-11,17,23-tris[N'-(4-nitrophenyl)ureido]-25,26,27,28-tetrapropoxycalix[4]arene