4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-4-nitropyran-3,5-dione

Base Information

Chemical Name:4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-4-nitropyran-3,5-dione
CAS No.:1198757-78-6
Molecular Formula:C₂₃H₂₃Cl₂NO₅
Molecular Weight:464.345
Hs Code.:

Synonyms:4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-4-nitropyran-3,5-dione

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Chemical Property of 4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-4-nitropyran-3,5-dione

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Technology Process of 4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-4-nitropyran-3,5-dione

There total 7 articles about 4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-4-nitropyran-3,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1312340-84-3
4-(2',4'-dichloro-4-ethyl[1,1'-biphenyl]-3-yl)-2,2,6,6-tetramethyl-2H-pyran-3,5(4H,6H)-dione

: 1198757-78-6
4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-4-nitropyran-3,5-dione

Guidance literature:: With nitric acid; acetic acid; sodium nitrite; at 20 ℃; for 2h;

Reference yield:

: 14922-91-9
2-ethyl-5-bromoaniline

: 1198757-78-6
4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-4-nitropyran-3,5-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / water / Reflux

1.2: 0.75 h / 0 - 5 °C / Cooling with ice

1.3: 20 - 80 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / -60 - 20 °C

2.2: -78 - 20 °C

3.1: mercury(II) diacetate / chloroform / 5 h / 40 °C / Inert atmosphere

4.1: dmap / chloroform; toluene / 2 h / 80 °C

5.1: cesium fluoride / 1,4-dioxane / 0.75 h / Inert atmosphere

5.2: 3 h / 100 °C / Inert atmosphere

6.1: nitric acid; acetic acid; sodium nitrite / 2 h / 20 °C

With dmap; sulfuric acid; isopropylmagnesium chloride; nitric acid; acetic acid; cesium fluoride; sodium nitrite; mercury(II) diacetate; In tetrahydrofuran; 1,4-dioxane; chloroform; water; toluene;

Reference yield:

: 1033760-94-9
4-bromo-1-ethyl-2-iodobenzene

: 1198757-78-6
4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-4-nitropyran-3,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / -60 - 20 °C

1.2: -78 - 20 °C

2.1: mercury(II) diacetate / chloroform / 5 h / 40 °C / Inert atmosphere

3.1: dmap / chloroform; toluene / 2 h / 80 °C

4.1: cesium fluoride / 1,4-dioxane / 0.75 h / Inert atmosphere

4.2: 3 h / 100 °C / Inert atmosphere

5.1: nitric acid; acetic acid; sodium nitrite / 2 h / 20 °C

With dmap; isopropylmagnesium chloride; nitric acid; acetic acid; cesium fluoride; sodium nitrite; mercury(II) diacetate; In tetrahydrofuran; 1,4-dioxane; chloroform; toluene;