3-[(1'-hydroxy-1'-(4''-nitrophenyl))methyl]-tetrahydropyran-4-one

Base Information

• Chemical Name: 3-[(1'-hydroxy-1'-(4''-nitrophenyl))methyl]-tetrahydropyran-4-one
• CAS No.: 1092371-49-7
• Molecular Formula: C₁₂H₁₃NO₅
• Molecular Weight: 251.239
• Mol file: 1092371-49-7.mol

Synonyms:3-[(1'-hydroxy-1'-(4''-nitrophenyl))methyl]-tetrahydropyran-4-one

Chemical Property of 3-[(1'-hydroxy-1'-(4''-nitrophenyl))methyl]-tetrahydropyran-4-one

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3-[(1'-hydroxy-1'-(4''-nitrophenyl))methyl]-tetrahydropyran-4-one

There total 10 articles about 3-[(1'-hydroxy-1'-(4''-nitrophenyl))methyl]-tetrahydropyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

Tetrahydro-4H-pyran-4-one (29943-42-8,143562-54-3) + 4-nitrobenzaldehdye (555-16-8) → (S)-3-((R)-hydroxy(4-nitrophenyl)methyl)-tetrahydropyran-4-one + (3R)-3-[(S)-hydroxy-(p-nitrophenyl)methyl]tetrahydropyran-4-one + 3-[(1′-hydroxy-1′-(4″-nitrophenyl))methyl]-tetrahydropyran-4-one (1092371-49-7)

Guidance literature:

With benzoic acid; In neat (no solvent); at 25 ℃; for 72h; enantioselective reaction; Inert atmosphere;

DOI:10.1002/hlca.201200422 DOI:10.1002/hlca.201200422

Reference yield: 69.0%

Tetrahydro-4H-pyran-4-one (29943-42-8,143562-54-3) + 4-nitrobenzaldehdye (555-16-8) → (3R)-3-[(S)-hydroxy-(p-nitrophenyl)methyl]tetrahydropyran-4-one + 3-[(1′-hydroxy-1′-(4″-nitrophenyl))methyl]-tetrahydropyran-4-one (1092371-49-7)

Guidance literature:

With water; benzoic acid; In neat (no solvent); at 25 ℃; for 72h; enantioselective reaction; Inert atmosphere;

DOI:10.1002/hlca.201200422 DOI:10.1002/hlca.201200422

Reference yield:

Tetrahydro-4H-pyran-4-one (29943-42-8,143562-54-3) + 4-nitrobenzaldehdye (555-16-8) → (S)-3-((R)-hydroxy(4-nitrophenyl)methyl)-tetrahydropyran-4-one + 3-[(1'-hydroxy-1'-(4''-nitrophenyl))methyl]-tetrahydropyran-4-one (1092371-49-7)

Guidance literature:

With O-(n-hexanoyl)-L-serine hydrochloride; triethylamine; In water; at 20 ℃; for 48h; optical yield given as %ee; enantioselective reaction;

DOI:10.1016/j.tet.2011.03.083

upstream raw materials:

Tetrahydro-4H-pyran-4-one

4-nitrobenzaldehdye