methyl 6-amino-1-(N,N-dimethylsulfamoyl)-2-[(2-phenylethyl)amino]-1H-benzimidazole-5-carboxylate

Base Information

• Chemical Name: methyl 6-amino-1-(N,N-dimethylsulfamoyl)-2-[(2-phenylethyl)amino]-1H-benzimidazole-5-carboxylate
• CAS No.: 1402168-50-6
• Molecular Formula: C₁₉H₂₃N₅O₄S
• Molecular Weight: 417.489

Synonyms:methyl 6-amino-1-(N,N-dimethylsulfamoyl)-2-[(2-phenylethyl)amino]-1H-benzimidazole-5-carboxylate

Chemical Property of methyl 6-amino-1-(N,N-dimethylsulfamoyl)-2-[(2-phenylethyl)amino]-1H-benzimidazole-5-carboxylate

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Technology Process of methyl 6-amino-1-(N,N-dimethylsulfamoyl)-2-[(2-phenylethyl)amino]-1H-benzimidazole-5-carboxylate

There total 3 articles about methyl 6-amino-1-(N,N-dimethylsulfamoyl)-2-[(2-phenylethyl)amino]-1H-benzimidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methyl 1-(N,N-dimethylsulfamoyl)-6-nitro-2-[(2-phenylethyl)amino]-1H-benzimidazole-5-carboxylate (1402168-43-7) → methyl 6-amino-1-(N,N-dimethylsulfamoyl)-2-[(2-phenylethyl)amino]-1H-benzimidazole-5-carboxylate (1402168-50-6)

Guidance literature:

With acetic acid; zinc; In water; at 25 ℃; Inert atmosphere;

DOI:10.1002/chem.201200809

Reference yield:

methyl 2-bromo-1-[(dimethylamino)sulfonyl]-6-nitro-1H-benzimidazole-5-carboxylate (1001242-31-4) → methyl 6-amino-1-(N,N-dimethylsulfamoyl)-2-[(2-phenylethyl)amino]-1H-benzimidazole-5-carboxylate (1402168-50-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ethyl acetate / 0 - 25 °C / Inert atmosphere

2: acetic acid; zinc / water / 25 °C / Inert atmosphere

With acetic acid; zinc; In water; ethyl acetate;

DOI:10.1002/chem.201200809

Reference yield:

phenethylamine (64-04-0) → methyl 6-amino-1-(N,N-dimethylsulfamoyl)-2-[(2-phenylethyl)amino]-1H-benzimidazole-5-carboxylate (1402168-50-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ethyl acetate / 0 - 25 °C / Inert atmosphere

2: acetic acid; zinc / water / 25 °C / Inert atmosphere

With acetic acid; zinc; In water; ethyl acetate;

DOI:10.1002/chem.201200809

upstream raw materials:

methyl 2-bromo-1-[(dimethylamino)sulfonyl]-6-nitro-1H-benzimidazole-5-carboxylate

methyl 1-(N,N-dimethylsulfamoyl)-6-nitro-2-[(2-phenylethyl)amino]-1H-benzimidazole-5-carboxylate

phenethylamine

Downstream raw materials:

2-[(2-phenylethyl)amino]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one

N,N-dimethyl-8-oxo-2-[(2-phenylethyl)amino]-7,8-dihydro-3H-imidazo[4,5-g]-quinazoline-3-sulfonamide

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