4-{3-[2-(4-methoxybenzylsulfanyl)pyridin-4-yl]-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile

Base Information

• Chemical Name: 4-{3-[2-(4-methoxybenzylsulfanyl)pyridin-4-yl]-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile
• CAS No.: 1043446-62-3
• Molecular Formula: C₂₆H₂₁F₃N₄O₂S₂
• Molecular Weight: 542.606
• Mol file: 1043446-62-3.mol

Synonyms:4-{3-[2-(4-methoxybenzylsulfanyl)pyridin-4-yl]-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile

Chemical Property of 4-{3-[2-(4-methoxybenzylsulfanyl)pyridin-4-yl]-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{3-[2-(4-methoxybenzylsulfanyl)pyridin-4-yl]-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile

There total 5 articles about 4-{3-[2-(4-methoxybenzylsulfanyl)pyridin-4-yl]-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-[2-(4-methoxybenzylsulfanyl)pyridin-4-ylamino]-2-methylpropionic acid methyl ester (1043446-61-2) + 4-isothiocyanato 2-(trifluoromethyl)benzonitrile (143782-23-4) → 4-{3-[2-(4-methoxybenzylsulfanyl)pyridin-4-yl]-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile (1043446-62-3)

Guidance literature:

With dmap; In toluene; at 80 ℃; for 48h;

DOI:10.1016/j.bmc.2010.10.023

Reference yield:

4-Amino-2-chloropyridine (14432-12-3) → 4-{3-[2-(4-methoxybenzylsulfanyl)pyridin-4-yl]-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile (1043446-62-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium tert-butylate / 1,3-dimethyl-2-imidazolidinone / 2 h / 120 °C / Microwave irradiation

2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 7 h / 60 - 80 °C

2.2: 0.25 h / 80 °C

3.1: tetrahydrofuran; diethyl ether

4.1: dmap / toluene / 48 h / 80 °C

With dmap; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; 1,3-dimethyl-2-imidazolidinone; diethyl ether; toluene;

DOI:10.1016/j.bmc.2010.10.023

Reference yield:

2-(4-methoxybenzylsulfanyl)pyridin-4-ylamine (1043446-60-1) → 4-{3-[2-(4-methoxybenzylsulfanyl)pyridin-4-yl]-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile (1043446-62-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 7 h / 60 - 80 °C

1.2: 0.25 h / 80 °C

2.1: tetrahydrofuran; diethyl ether

3.1: dmap / toluene / 48 h / 80 °C

With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; toluene;

DOI:10.1016/j.bmc.2010.10.023

upstream raw materials:

2-[2-(4-methoxybenzylsulfanyl)pyridin-4-ylamino]-2-methylpropionic acid methyl ester

4-isothiocyanato 2-(trifluoromethyl)benzonitrile

4-Amino-2-chloropyridine

2-(4-methoxybenzylsulfanyl)pyridin-4-ylamine

Downstream raw materials:

4-[3-(2-mercaptopyridin-4-yl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile

4-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]pyridine-2-sulfonic acid amide