(3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]-4-methylpyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine p-toluenesulfonate

Base Information

Chemical Name:(3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]-4-methylpyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine p-toluenesulfonate
CAS No.:1351338-59-4
Molecular Formula:C₇H₈O₃S*C₂₆H₃₂F₃N₇O₂
Molecular Weight:703.786
Hs Code.:

(3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]-4-methylpyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine p-toluenesulfonate

Synonyms:(3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]-4-methylpyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine p-toluenesulfonate

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Chemical Property of (3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]-4-methylpyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine p-toluenesulfonate

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Technology Process of (3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]-4-methylpyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine p-toluenesulfonate

There total 12 articles about (3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]-4-methylpyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351345-55-5
[(3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]-4-methylpyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

: 104-15-4
toluene-4-sulfonic acid

: 1351338-59-4
(3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]-4-methylpyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine p-toluenesulfonate

Guidance literature:: [(3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]-4-methylpyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; diethyl ether; at 20 ℃; for 16h; Inert atmosphere;

With sodium hydrogencarbonate; In 1,4-dioxane; methanol; diethyl ether;

toluene-4-sulfonic acid; In methanol;

Reference yield:

: 936251-01-3
[(trans)-1-benzyl-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

: 1351338-59-4
(3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]-4-methylpyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine p-toluenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / 5%-palladium/activated carbon / toluene; industrial methylated spirit / 72 h / Inert atmosphere; autoclave

2: (2S)-2-(6-methoxy(2-naphthyl))propanoic acid / ethanol / 20 °C / Reflux

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 168 h / 80 °C / sealed tube

4: hydrogenchloride / 1,4-dioxane; diethyl ether / 16 h / 20 °C / Inert atmosphere

With hydrogenchloride; hydrogen; (2S)-2-(6-methoxy(2-naphthyl))propanoic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 5%-palladium/activated carbon; In 1,4-dioxane; industrial methylated spirit; diethyl ether; ethanol; dimethyl sulfoxide; toluene;

Reference yield:

: (trans)-1-benzyl-3-(2,4,5-trifluorophenyl)-4-nitropyrrolidine

: 1351338-59-4
(3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]-4-methylpyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine p-toluenesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: zinc; acetic acid / industrial methylated spirit / 65 °C

2: triethylamine / tetrahydrofuran / 16.08 h / 0 - 20 °C

3: hydrogen / 5%-palladium/activated carbon / toluene; industrial methylated spirit / 72 h / Inert atmosphere; autoclave

4: (2S)-2-(6-methoxy(2-naphthyl))propanoic acid / ethanol / 20 °C / Reflux

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 168 h / 80 °C / sealed tube

6: hydrogenchloride / 1,4-dioxane; diethyl ether / 16 h / 20 °C / Inert atmosphere

With hydrogenchloride; hydrogen; (2S)-2-(6-methoxy(2-naphthyl))propanoic acid; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; zinc; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; industrial methylated spirit; diethyl ether; ethanol; dimethyl sulfoxide; toluene;