2'-benzyl 2-tert-butyl 4-methyl 4'-[(trifluoroacetyl)amino]biphenyl-2,2',4-tricarboxylate

Base Information

Chemical Name:2'-benzyl 2-tert-butyl 4-methyl 4'-[(trifluoroacetyl)amino]biphenyl-2,2',4-tricarboxylate
CAS No.:917113-88-3
Molecular Formula:C₂₉H₂₆F₃NO₇
Molecular Weight:557.523
Hs Code.:

Synonyms:2'-benzyl 2-tert-butyl 4-methyl 4'-[(trifluoroacetyl)amino]biphenyl-2,2',4-tricarboxylate

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Chemical Property of 2'-benzyl 2-tert-butyl 4-methyl 4'-[(trifluoroacetyl)amino]biphenyl-2,2',4-tricarboxylate

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Technology Process of 2'-benzyl 2-tert-butyl 4-methyl 4'-[(trifluoroacetyl)amino]biphenyl-2,2',4-tricarboxylate

There total 10 articles about 2'-benzyl 2-tert-butyl 4-methyl 4'-[(trifluoroacetyl)amino]biphenyl-2,2',4-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 790230-26-1
2'-benzyl 2-tert-butyl 4-methyl 4'-aminobiphenyl-2,2',4-tricarboxylate

: 407-25-0
trifluoroacetic anhydride

: 917113-88-3
2'-benzyl 2-tert-butyl 4-methyl 4'-[(trifluoroacetyl)amino]biphenyl-2,2',4-tricarboxylate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/j.bmc.2006.09.071

Reference yield:

: 576170-38-2
3-(tert-butyl) 1-methyl 4-hydroxyisophthalate

: 917113-88-3
2'-benzyl 2-tert-butyl 4-methyl 4'-[(trifluoroacetyl)amino]biphenyl-2,2',4-tricarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 13.3 g / pyridine / CH₂Cl₂ / 0.5 h / 20 °C

2.1: bis(pinacolato)diboron; PPh₃; AcOK / PdCl₂(PPh₃)2 / toluene / Heating

2.2: 74 percent / Na₂CO₃ / Pd(PPh₃)2 / toluene / Heating

3.1: 72 percent / Fe; AcOH / 1 h / 60 °C

4.1: 70 percent / pyridine / CH₂Cl₂ / 12 h / 20 °C

With pyridine; potassium acetate; iron; acetic acid; triphenylphosphine; bis(pinacol)diborane; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; toluene; 2.2: Suzuki coupling;
DOI:10.1016/j.bmc.2006.09.071

Reference yield:

: 790230-23-8
3-tert-butyl 1-methyl 4-{[(trifluoromethyl)sulfonyl]oxy}isophthalate

: 917113-88-3
2'-benzyl 2-tert-butyl 4-methyl 4'-[(trifluoroacetyl)amino]biphenyl-2,2',4-tricarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis(pinacolato)diboron; PPh₃; AcOK / PdCl₂(PPh₃)2 / toluene / Heating

1.2: 74 percent / Na₂CO₃ / Pd(PPh₃)2 / toluene / Heating

2.1: 72 percent / Fe; AcOH / 1 h / 60 °C

3.1: 70 percent / pyridine / CH₂Cl₂ / 12 h / 20 °C

With pyridine; potassium acetate; iron; acetic acid; triphenylphosphine; bis(pinacol)diborane; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; toluene; 1.2: Suzuki coupling;
DOI:10.1016/j.bmc.2006.09.071