1-(2-bromo-5-methylphenyl)-5-(4,5-methylendioxy-2-nitrophenyl)pyrazole

Base Information

• Chemical Name: 1-(2-bromo-5-methylphenyl)-5-(4,5-methylendioxy-2-nitrophenyl)pyrazole
• CAS No.: 1293935-96-2
• Molecular Formula: C₁₇H₁₂BrN₃O₄
• Molecular Weight: 402.204

Synonyms:1-(2-bromo-5-methylphenyl)-5-(4,5-methylendioxy-2-nitrophenyl)pyrazole

Chemical Property of 1-(2-bromo-5-methylphenyl)-5-(4,5-methylendioxy-2-nitrophenyl)pyrazole

Chemical Property:

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Technology Process of 1-(2-bromo-5-methylphenyl)-5-(4,5-methylendioxy-2-nitrophenyl)pyrazole

There total 2 articles about 1-(2-bromo-5-methylphenyl)-5-(4,5-methylendioxy-2-nitrophenyl)pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(2-bromo-5-methylphenyl)hydrazine hydrochloride (60481-41-6) + (E)-3-(N,N-dimethylamino)-1-(4,5-methylenedioxy-2-nitrophenyl)-2-propen-1-one (844887-98-5) → 1-(2-bromo-5-methylphenyl)-5-(4,5-methylendioxy-2-nitrophenyl)pyrazole (1293935-96-2)

Guidance literature:

In methanol; water; at 135 ℃; for 2h; regioselective reaction; Reflux;

DOI:10.1039/c0ob00812e

Reference yield:

2-bromo-5-methylaniline (53078-85-6) → 1-(2-bromo-5-methylphenyl)-5-(4,5-methylendioxy-2-nitrophenyl)pyrazole (1293935-96-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; tin(ll) chloride; sodium nitrite / water / 24 h / 20 °C

2: methanol; water / 2 h / 135 °C / Reflux

With hydrogenchloride; tin(ll) chloride; sodium nitrite; In methanol; water;

DOI:10.1039/c0ob00812e

Reference yield: 77.0%

1-(2-bromo-5-methylphenyl)-5-(4,5-methylendioxy-2-nitrophenyl)pyrazole (1293935-96-2) → 5-(2-amino-4,5-methylenedioxyphenyl)-1-(2-bromo-5-methylphenyl)pyrazole (1293936-08-9)

Guidance literature:

With iron; acetic acid; In ethanol; water; for 3h; Reflux;

DOI:10.1039/c0ob00812e

upstream raw materials:

(2-bromo-5-methylphenyl)hydrazine hydrochloride

(E)-3-(N,N-dimethylamino)-1-(4,5-methylenedioxy-2-nitrophenyl)-2-propen-1-one

2-bromo-5-methylaniline

Downstream raw materials:

5-(2-amino-4,5-methylenedioxyphenyl)-1-(2-bromo-5-methylphenyl)pyrazole

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