N-[3-(Benzo[b]thiophen-3-ylmethoxy)-phenyl]-C,C,C-trifluoro-methanesulfonamide

Base Information

• Chemical Name: N-[3-(Benzo[b]thiophen-3-ylmethoxy)-phenyl]-C,C,C-trifluoro-methanesulfonamide
• CAS No.: 119481-25-3
• Molecular Formula: C₁₆H₁₂F₃NO₃S₂
• Molecular Weight: 387.403

Synonyms:N-[3-(Benzo[b]thiophen-3-ylmethoxy)-phenyl]-C,C,C-trifluoro-methanesulfonamide

Chemical Property of N-[3-(Benzo[b]thiophen-3-ylmethoxy)-phenyl]-C,C,C-trifluoro-methanesulfonamide

Chemical Property:

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Technology Process of N-[3-(Benzo[b]thiophen-3-ylmethoxy)-phenyl]-C,C,C-trifluoro-methanesulfonamide

There total 4 articles about N-[3-(Benzo[b]thiophen-3-ylmethoxy)-phenyl]-C,C,C-trifluoro-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

trifluoromethylsulfonic anhydride (358-23-6) + 3-(Benzo[b]thiophen-3-ylmethoxy)-phenylamine (119481-53-7) → N-[3-(Benzo[b]thiophen-3-ylmethoxy)-phenyl]-C,C,C-trifluoro-methanesulfonamide (119481-25-3)

Guidance literature:

With triethylamine; In dichloromethane; -70 deg C to 10 deg C;

DOI:10.1021/jm00126a006

Reference yield:

3-chloromethylbenzothiophene (3216-47-5) → N-[3-(Benzo[b]thiophen-3-ylmethoxy)-phenyl]-C,C,C-trifluoro-methanesulfonamide (119481-25-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Cs₂CO₃, KI / acetone / Heating

2: H₂ / PtO₂ / ethanol / 1810.02 Torr

3: 53 percent / Et₃N / CH₂Cl₂ / -70 deg C to 10 deg C

With hydrogen; caesium carbonate; triethylamine; potassium iodide; platinum(IV) oxide; In ethanol; dichloromethane; acetone;

DOI:10.1021/jm00126a006

Reference yield:

meta-nitrophenol (554-84-7) → N-[3-(Benzo[b]thiophen-3-ylmethoxy)-phenyl]-C,C,C-trifluoro-methanesulfonamide (119481-25-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Cs₂CO₃, KI / acetone / Heating

2: H₂ / PtO₂ / ethanol / 1810.02 Torr

3: 53 percent / Et₃N / CH₂Cl₂ / -70 deg C to 10 deg C

With hydrogen; caesium carbonate; triethylamine; potassium iodide; platinum(IV) oxide; In ethanol; dichloromethane; acetone;

DOI:10.1021/jm00126a006

upstream raw materials:

trifluoromethylsulfonic anhydride

3-(Benzo[b]thiophen-3-ylmethoxy)-phenylamine

3-chloromethylbenzothiophene

meta-nitrophenol

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