ethyl 2-(2-allyl-4-chloro-phenoxy)-3-oxo-3-phenyl-propionate

Base Information

• Chemical Name: ethyl 2-(2-allyl-4-chloro-phenoxy)-3-oxo-3-phenyl-propionate
• CAS No.: 370862-21-8
• Molecular Formula: C₂₀H₁₉ClO₄
• Molecular Weight: 358.821
• Mol file: 370862-21-8.mol

Synonyms:ethyl 2-(2-allyl-4-chloro-phenoxy)-3-oxo-3-phenyl-propionate

Chemical Property of ethyl 2-(2-allyl-4-chloro-phenoxy)-3-oxo-3-phenyl-propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(2-allyl-4-chloro-phenoxy)-3-oxo-3-phenyl-propionate

There total 2 articles about ethyl 2-(2-allyl-4-chloro-phenoxy)-3-oxo-3-phenyl-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ethyl 2-chloro-3-oxo-3-phenylpropionate (41381-97-9,146368-56-1) + 2-allyl-4-chlorophenol (13997-73-4) → ethyl 2-(2-allyl-4-chloro-phenoxy)-3-oxo-3-phenyl-propionate (370862-21-8)

Guidance literature:

With sodium hydroxide; In Dimethyl ether; toluene; at 80 ℃; for 0.333333h;

DOI:10.1016/j.tet.2004.03.015

Reference yield: 83.0%

ethyl 2-chloro-3-oxo-3-phenylpropionate (41381-97-9,146368-56-1) + Sodium; 2-allyl-4-chloro-phenolate (118537-91-0) → ethyl 2-(2-allyl-4-chloro-phenoxy)-3-oxo-3-phenyl-propionate (370862-21-8)

Guidance literature:

In diethylene glycol dimethyl ether; at 80 ℃;

DOI:10.1039/b203054c

Reference yield:

ethyl 2-(2-allyl-4-chloro-phenoxy)-3-oxo-3-phenyl-propionate (370862-21-8) → ethyl cis-2-chloro-4-[3-(4-chloro-phenyl)-ureido]-6-oxo-6,11,11a,12-tetrahydrobenzo[b]xanthene-5a-carboxylate

Guidance literature:

Multi-step reaction with 4 steps

1: 54 percent / propionic acid; acetic acid; manganese(III) acetate / acetic anhydride / 48 h / 20 °C

2: 95 percent / acetic anhydride; sulfuric acid; nitric acid / -10 - -5 °C

3: 90 percent / SnCl₂*2H₂O / methanol / 20 °C

4: 80 percent / toluene / 20 °C

With sulfuric acid; nitric acid; manganese triacetate; acetic anhydride; acetic acid; propionic acid; tin(ll) chloride; acetic anhydride; In methanol; toluene;

DOI:10.1016/j.tet.2004.03.015

upstream raw materials:

ethyl 2-chloro-3-oxo-3-phenylpropionate

Sodium; 2-allyl-4-chloro-phenolate

2-allyl-4-chlorophenol