Technology Process of 5'-bromo-2',4'-diisopropoxybenzyl 2-hydroxy-4-isopropoxyphenyl ketone
There total 8 articles about 5'-bromo-2',4'-diisopropoxybenzyl 2-hydroxy-4-isopropoxyphenyl ketone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 85 percent / K2CO3 / dimethylformamide / 3.3 h / 55 °C
2: 82 percent / thallium trinitrate; aq. perchloric acid / methanol / 4.3 h / 20 °C
3: 99 percent / NBS; SiO2 (Micro Bead 3 Angstroem) / CHCl3 / 1.17 h / 20 °C
4: 78 percent / aq. NaOH / methanol / 3.5 h / 20 °C
5: (COCl)2 / 2.5 h / 20 °C
6: 0.707 g / SnCl4 / CH2Cl2 / 1.08 h / -78 °C
7: 71 percent / conc. H2SO4; AcOH / 4 h / 50 °C
With
sodium hydroxide; N-Bromosuccinimide; perchloric acid; oxalyl dichloride; SiO2 (Micro Bead 3 Angstroem); sulfuric acid; tin(IV) chloride; potassium carbonate; acetic acid; thallium(III) nitrate;
In
methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
6: Friedel-Crafts acylation;
DOI:10.3987/com-04-10060
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 0.707 g / SnCl4 / CH2Cl2 / 1.08 h / -78 °C
2: 71 percent / conc. H2SO4; AcOH / 4 h / 50 °C
With
sulfuric acid; tin(IV) chloride; acetic acid;
In
dichloromethane;
1: Friedel-Crafts acylation;
DOI:10.3987/com-04-10060
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 77 percent / dimethylformamide / 12.5 h / 55 °C
2: 0.707 g / SnCl4 / CH2Cl2 / 1.08 h / -78 °C
3: 71 percent / conc. H2SO4; AcOH / 4 h / 50 °C
With
sulfuric acid; tin(IV) chloride; acetic acid;
In
dichloromethane; N,N-dimethyl-formamide;
2: Friedel-Crafts acylation;
DOI:10.3987/com-04-10060
