Technology Process of 9--2-N-(phenylacetyl)guanine
There total 12 articles about 9--2-N-(phenylacetyl)guanine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 50 percent / POCl3, Zn-Cu couple / diethyl ether / 18 h / Heating
2: 68 percent / Zn, CH3COOH / 4 h / Heating
3: L-Selectride / tetrahydrofuran / -78 °C
4: 60 percent / PPh3, diethyl azodicarboxylate / tetrahydrofuran / 24 h
5: 1) 3-chloroperbenzoic acid, 2) butane-2,3-dione monoxime, N1,N1,N3,N3-tetramethylguanidine / 1) CH2Cl2, room temperature, 1 h, 2) CH3CN, 5 min
With
1,1,3,3-tetramethylguanidine; L-Selectride; copper; acetic acid; butane-2,3-dione mono-oxime; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; zinc; diethylazodicarboxylate; trichlorophosphate;
In
tetrahydrofuran; diethyl ether;
DOI:10.1039/P19950002281
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 68 percent / Zn, CH3COOH / 4 h / Heating
2: L-Selectride / tetrahydrofuran / -78 °C
3: 60 percent / PPh3, diethyl azodicarboxylate / tetrahydrofuran / 24 h
4: 1) 3-chloroperbenzoic acid, 2) butane-2,3-dione monoxime, N1,N1,N3,N3-tetramethylguanidine / 1) CH2Cl2, room temperature, 1 h, 2) CH3CN, 5 min
With
1,1,3,3-tetramethylguanidine; L-Selectride; acetic acid; butane-2,3-dione mono-oxime; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; zinc; diethylazodicarboxylate;
In
tetrahydrofuran;
DOI:10.1039/P19950002281
- Guidance literature:
-
Multi-step reaction with 3 steps
1: L-Selectride / tetrahydrofuran / -78 °C
2: 60 percent / PPh3, diethyl azodicarboxylate / tetrahydrofuran / 24 h
3: 1) 3-chloroperbenzoic acid, 2) butane-2,3-dione monoxime, N1,N1,N3,N3-tetramethylguanidine / 1) CH2Cl2, room temperature, 1 h, 2) CH3CN, 5 min
With
1,1,3,3-tetramethylguanidine; L-Selectride; butane-2,3-dione mono-oxime; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran;
DOI:10.1039/P19950002281
