(1R,3aS,4R,8aS,8bR)-2-[(1,3-benzodioxol-5-yl)methyl]-4-(4-bromophenyl)-1-[(4-methylphenyl)sulfonyl]-perhydropyrrolo[3,4-a]pyrrolizin-3-one

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Chemical Name:(1R,3aS,4R,8aS,8bR)-2-[(1,3-benzodioxol-5-yl)methyl]-4-(4-bromophenyl)-1-[(4-methylphenyl)sulfonyl]-perhydropyrrolo[3,4-a]pyrrolizin-3-one
CAS No.:192067-25-7
Molecular Formula:C₃₀H₂₉BrN₂O₅S
Molecular Weight:609.541
Hs Code.:

Synonyms:(1R,3aS,4R,8aS,8bR)-2-[(1,3-benzodioxol-5-yl)methyl]-4-(4-bromophenyl)-1-[(4-methylphenyl)sulfonyl]-perhydropyrrolo[3,4-a]pyrrolizin-3-one

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Chemical Property of (1R,3aS,4R,8aS,8bR)-2-[(1,3-benzodioxol-5-yl)methyl]-4-(4-bromophenyl)-1-[(4-methylphenyl)sulfonyl]-perhydropyrrolo[3,4-a]pyrrolizin-3-one

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Technology Process of (1R,3aS,4R,8aS,8bR)-2-[(1,3-benzodioxol-5-yl)methyl]-4-(4-bromophenyl)-1-[(4-methylphenyl)sulfonyl]-perhydropyrrolo[3,4-a]pyrrolizin-3-one

There total 5 articles about (1R,3aS,4R,8aS,8bR)-2-[(1,3-benzodioxol-5-yl)methyl]-4-(4-bromophenyl)-1-[(4-methylphenyl)sulfonyl]-perhydropyrrolo[3,4-a]pyrrolizin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: p-toluenesulfonic acid

: 192067-01-9
methyl (R)-{(1R,3aS,4R,8aS,8bR)-2-[(1,3-benzodioxol-5-yl)methyl]-4-(4-bromophenyl)-3-oxoperhydropyrrolo[3,4-a]pyrrolizin-1-yloxy}phenylacetate

: 192067-25-7
(1R,3aS,4R,8aS,8bR)-2-[(1,3-benzodioxol-5-yl)methyl]-4-(4-bromophenyl)-1-[(4-methylphenyl)sulfonyl]-perhydropyrrolo[3,4-a]pyrrolizin-3-one

Guidance literature:: With calcium chloride; In dichloromethane; for 12h;
DOI:10.1002/(SICI)1522-2675(20000510)83:5<855::AID-HLCA855>3.0.CO;2-9

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 192067-25-7
(1R,3aS,4R,8aS,8bR)-2-[(1,3-benzodioxol-5-yl)methyl]-4-(4-bromophenyl)-1-[(4-methylphenyl)sulfonyl]-perhydropyrrolo[3,4-a]pyrrolizin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 20 percent / dimethylformamide / 10.5 h / 80 °C

2: Li[Et₃BH] / tetrahydrofuran / 0.5 h / -78 °C

3: 5.34 g / PPTS / toluene / 6 h / Heating

4: 91 percent / CaCl₂ / CH₂Cl₂ / 12 h

With pyridinium p-toluenesulfonate; lithium triethylborohydride; calcium chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 1: Condensation / 2: Reduction / 3: Etherification / 4: Substitution;
DOI:10.1002/(SICI)1522-2675(20000510)83:5<855::AID-HLCA855>3.0.CO;2-9

Reference yield:

: 182191-39-5
N-(3,4-methylenedioxybenzyl)maleimide

: 192067-25-7
(1R,3aS,4R,8aS,8bR)-2-[(1,3-benzodioxol-5-yl)methyl]-4-(4-bromophenyl)-1-[(4-methylphenyl)sulfonyl]-perhydropyrrolo[3,4-a]pyrrolizin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 20 percent / dimethylformamide / 10.5 h / 80 °C

2: Li[Et₃BH] / tetrahydrofuran / 0.5 h / -78 °C

3: 5.34 g / PPTS / toluene / 6 h / Heating

4: 91 percent / CaCl₂ / CH₂Cl₂ / 12 h

With pyridinium p-toluenesulfonate; lithium triethylborohydride; calcium chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 1: Condensation / 2: Reduction / 3: Etherification / 4: Substitution;
DOI:10.1002/(SICI)1522-2675(20000510)83:5<855::AID-HLCA855>3.0.CO;2-9