6-(3-Benzyl-1,9-diazaspiro[5.5]undecan-9-yl)-9H-purine

Base Information

• Chemical Name: 6-(3-Benzyl-1,9-diazaspiro[5.5]undecan-9-yl)-9H-purine
• CAS No.: 1452809-01-6
• Molecular Formula: C₂₁H₂₆N₆
• Molecular Weight: 362.478
• Mol file: 1452809-01-6.mol

Synonyms:6-(3-Benzyl-1,9-diazaspiro[5.5]undecan-9-yl)-9H-purine

Chemical Property of 6-(3-Benzyl-1,9-diazaspiro[5.5]undecan-9-yl)-9H-purine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(3-Benzyl-1,9-diazaspiro[5.5]undecan-9-yl)-9H-purine

There total 7 articles about 6-(3-Benzyl-1,9-diazaspiro[5.5]undecan-9-yl)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-benzyl-1,9-diazaspiro[5.5]undecane hydrochloride + 6-chloropurine (87-42-3) → 6-(3-Benzyl-1,9-diazaspiro[5.5]undecan-9-yl)-9H-purine (1452809-01-6)

Guidance literature:

With triethylamine; In butan-1-ol; at 100 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmc.2013.07.021

Reference yield:

N-(4-allyl-1-benzylpiperidin-4-yl)-N,2-dibenzylacrylamide (1452809-29-8) → 6-(3-Benzyl-1,9-diazaspiro[5.5]undecan-9-yl)-9H-purine (1452809-01-6)

Guidance literature:

Multi-step reaction with 5 steps

1: Hoveyda-Grubbs catalyst second generation; titanium(IV) isopropylate / dichloromethane / 31 h / 40 °C / Inert atmosphere

2: hydrogenchloride; hydrogen; palladium 10% on activated carbon / tetrahydrofuran; ethanol / 48 h / 30 °C / 760.05 Torr

3: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 50 °C / Inert atmosphere

4: hydrogenchloride; hydrogen; palladium 10% on activated carbon / methanol / 25 h / 40 °C / 760.05 Torr

5: triethylamine / butan-1-ol / 2 h / 100 °C / Inert atmosphere

With titanium(IV) isopropylate; hydrogenchloride; lithium aluminium tetrahydride; Hoveyda-Grubbs catalyst second generation; palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; butan-1-ol;

DOI:10.1016/j.bmc.2013.07.021

Reference yield:

1,3,9-Tribenzyl-1,9-diazaspiro[5.5]undec-3-en-2-one (1452808-99-9) → 6-(3-Benzyl-1,9-diazaspiro[5.5]undecan-9-yl)-9H-purine (1452809-01-6)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride; hydrogen; palladium 10% on activated carbon / tetrahydrofuran; ethanol / 48 h / 30 °C / 760.05 Torr

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 50 °C / Inert atmosphere

3: hydrogenchloride; hydrogen; palladium 10% on activated carbon / methanol / 25 h / 40 °C / 760.05 Torr

4: triethylamine / butan-1-ol / 2 h / 100 °C / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; methanol; ethanol; butan-1-ol;

DOI:10.1016/j.bmc.2013.07.021

upstream raw materials:

N-(4-allyl-1-benzylpiperidin-4-yl)-N,2-dibenzylacrylamide

1,3,9-Tribenzyl-1,9-diazaspiro[5.5]undec-3-en-2-one

1,3,9-tribenzyl-1,9-diazaspiro[5.5]undecan-2-one hydrochloride

6-chloropurine