5'-O-Dimethoxytritylthymidylyl-(3'-5')-3'-O-benzoylthymidylyl O-<2-(p-nitrophenyl)ethyl> phosphite

Base Information

Chemical Name:5'-O-Dimethoxytritylthymidylyl-(3'-5')-3'-O-benzoylthymidylyl O-<2-(p-nitrophenyl)ethyl> phosphite
CAS No.:91876-68-5
Molecular Formula:C₅₆H₅₆N₅O₁₆P
Molecular Weight:1086.06
Hs Code.:

Synonyms:5'-O-Dimethoxytritylthymidylyl-(3'-5')-3'-O-benzoylthymidylyl O-<2-(p-nitrophenyl)ethyl> phosphite

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Chemical Property of 5'-O-Dimethoxytritylthymidylyl-(3'-5')-3'-O-benzoylthymidylyl O-<2-(p-nitrophenyl)ethyl> phosphite

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Technology Process of 5'-O-Dimethoxytritylthymidylyl-(3'-5')-3'-O-benzoylthymidylyl O-<2-(p-nitrophenyl)ethyl> phosphite

There total 3 articles about 5'-O-Dimethoxytritylthymidylyl-(3'-5')-3'-O-benzoylthymidylyl O-<2-(p-nitrophenyl)ethyl> phosphite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 91876-64-1,125277-49-8,125277-50-1
C₄₃H₄₇N₄O₁₁P

: 17331-53-2
3'-O-benzoylthymidine

: 91876-68-5
5'-O-Dimethoxytritylthymidylyl-(3'-5')-3'-O-benzoylthymidylyl O-<2-(p-nitrophenyl)ethyl> phosphite

Guidance literature:

Reference yield:

: 91876-63-0
Chloro-<2-(p-nitrophenyl)ethyl>morpholinophosphine

: 91876-68-5
5'-O-Dimethoxytritylthymidylyl-(3'-5')-3'-O-benzoylthymidylyl O-<2-(p-nitrophenyl)ethyl> phosphite

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / EtN(i-Pr)2 / CH₂Cl₂ / 0.25 h

2: 67 percent / tetrazole / CH₂Cl₂ / 0.25 h / Ambient temperature

With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1055/s-1989-27299

Reference yield:

: 76101-32-1
2-(4-nitrophenyl)ethyl phosphorodichloridite

: 91876-68-5
5'-O-Dimethoxytritylthymidylyl-(3'-5')-3'-O-benzoylthymidylyl O-<2-(p-nitrophenyl)ethyl> phosphite

Guidance literature:: Multi-step reaction with 3 steps

1: -20 deg C, 1 h, then r.t., 2 h

2: 94 percent / EtN(i-Pr)2 / CH₂Cl₂ / 0.25 h

3: 67 percent / tetrazole / CH₂Cl₂ / 0.25 h / Ambient temperature

With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1055/s-1989-27299