N-(2-aminophenyl)-4-methyl-3-(4-(pyridin-2-ylmethoxy)benzamido)benzamide

Base Information

Chemical Name:N-(2-aminophenyl)-4-methyl-3-(4-(pyridin-2-ylmethoxy)benzamido)benzamide
CAS No.:1391913-26-0
Molecular Formula:C₂₇H₂₄N₄O₃
Molecular Weight:452.513
Hs Code.:

Synonyms:N-(2-aminophenyl)-4-methyl-3-(4-(pyridin-2-ylmethoxy)benzamido)benzamide

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Chemical Property of N-(2-aminophenyl)-4-methyl-3-(4-(pyridin-2-ylmethoxy)benzamido)benzamide

Chemical Property:

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Technology Process of N-(2-aminophenyl)-4-methyl-3-(4-(pyridin-2-ylmethoxy)benzamido)benzamide

There total 4 articles about N-(2-aminophenyl)-4-methyl-3-(4-(pyridin-2-ylmethoxy)benzamido)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1126367-80-3
4-methyl-3-(4-(pyridin-2-ylmethoxy)benzamido)benzoic acid

: 95-54-5
1,2-diamino-benzene

: 1391913-26-0
N-(2-aminophenyl)-4-methyl-3-(4-(pyridin-2-ylmethoxy)benzamido)benzamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h;
DOI:10.1016/j.bmcl.2012.04.104

Reference yield:

: 120-47-8
Ethyl 4-hydroxybenzoate

: 1391913-26-0
N-(2-aminophenyl)-4-methyl-3-(4-(pyridin-2-ylmethoxy)benzamido)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / water; acetonitrile

2: sodium hydroxide / ethanol / 20 °C / Reflux

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere

4: sodium hydroxide / methanol; water / 2 h / 70 °C

5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

With potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2012.04.104

Reference yield:

: 50596-36-6
4-(pyridin-2-ylmethoxy)benzoic acid

: 1391913-26-0
N-(2-aminophenyl)-4-methyl-3-(4-(pyridin-2-ylmethoxy)benzamido)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere

2: sodium hydroxide / methanol; water / 2 h / 70 °C

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.04.104