Technology Process of Ethyl 2--4-(2-methyl-1,3-dioxolan-2-yl)cyclohexane-1-carboxylate
There total 10 articles about Ethyl 2--4-(2-methyl-1,3-dioxolan-2-yl)cyclohexane-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 73 percent / hydroxylamine-O-sulfonic acid / methanol; H2O / 1) room temperature, 1 h; 2) 50 deg C, 1 h
2: 1.) potassium hydride / 1) THF, room temperature, 1 h; 2) HMPA, THF, -20 deg C (3 h), 0 deg C (3 h), room temperature (12 h)
With
potassium hydride; hydroxylamine-O-sulfonic acid;
In
methanol; water;
DOI:10.1021/ja00538a029
- Guidance literature:
-
Multi-step reaction with 4 steps
1: osmium tetroxide, potassium chlorate, water / tetrahydrofuran / 6 h / Ambient temperature
2: 570 mg / sodium periodate, water / 2-methyl-propan-2-ol / 2 h / Ambient temperature
3: 73 percent / hydroxylamine-O-sulfonic acid / methanol; H2O / 1) room temperature, 1 h; 2) 50 deg C, 1 h
4: 1.) potassium hydride / 1) THF, room temperature, 1 h; 2) HMPA, THF, -20 deg C (3 h), 0 deg C (3 h), room temperature (12 h)
With
sodium periodate; osmium(VIII) oxide; potassium chlorate; water; potassium hydride; hydroxylamine-O-sulfonic acid;
In
tetrahydrofuran; methanol; water; tert-butyl alcohol;
DOI:10.1021/ja00538a029
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium hydrosulfite / H2O; diethyl ether / 0.33 h
2: 1.) sodium hydride / 1) THF; 2) THF, reflux, 2 h
3: osmium tetroxide, potassium chlorate, water / tetrahydrofuran / 6 h / Ambient temperature
4: 570 mg / sodium periodate, water / 2-methyl-propan-2-ol / 2 h / Ambient temperature
5: 73 percent / hydroxylamine-O-sulfonic acid / methanol; H2O / 1) room temperature, 1 h; 2) 50 deg C, 1 h
6: 1.) potassium hydride / 1) THF, room temperature, 1 h; 2) HMPA, THF, -20 deg C (3 h), 0 deg C (3 h), room temperature (12 h)
With
sodium periodate; sodium disulfite; osmium(VIII) oxide; potassium chlorate; water; potassium hydride; sodium hydride; hydroxylamine-O-sulfonic acid;
In
tetrahydrofuran; methanol; diethyl ether; water; tert-butyl alcohol;
DOI:10.1021/ja00538a029
