2,6-Dichloro-benzoic acid (S)-3-{2-[5-benzyloxycarbonylamino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamino}-4-tert-butoxycarbonyl-2-oxo-butyl ester

Base Information

Chemical Name:2,6-Dichloro-benzoic acid (S)-3-{2-[5-benzyloxycarbonylamino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamino}-4-tert-butoxycarbonyl-2-oxo-butyl ester
CAS No.:173305-27-6
Molecular Formula:C₃₆H₃₃Cl₂FN₄O₉
Molecular Weight:755.584
Hs Code.:

2,6-Dichloro-benzoic acid (S)-3-{2-[5-benzyloxycarbonylamino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamino}-4-tert-butoxycarbonyl-2-oxo-butyl ester

Synonyms:2,6-Dichloro-benzoic acid (S)-3-{2-[5-benzyloxycarbonylamino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamino}-4-tert-butoxycarbonyl-2-oxo-butyl ester

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Chemical Property of 2,6-Dichloro-benzoic acid (S)-3-{2-[5-benzyloxycarbonylamino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamino}-4-tert-butoxycarbonyl-2-oxo-butyl ester

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Technology Process of 2,6-Dichloro-benzoic acid (S)-3-{2-[5-benzyloxycarbonylamino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamino}-4-tert-butoxycarbonyl-2-oxo-butyl ester

There total 1 articles about 2,6-Dichloro-benzoic acid (S)-3-{2-[5-benzyloxycarbonylamino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamino}-4-tert-butoxycarbonyl-2-oxo-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 148747-76-6
[5-[(benzyloxycarbonyl)amino]-6-oxo-2-(4-fluorophenyl)-1,6-dihydro-1-pyrimidinyl]acetic acid

: 2,6-Dichloro-benzoic acid (S)-3-amino-4-tert-butoxycarbonyl-2-oxo-butyl ester; hydrochloride

: 173305-27-6
2,6-Dichloro-benzoic acid (S)-3-{2-[5-benzyloxycarbonylamino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamino}-4-tert-butoxycarbonyl-2-oxo-butyl ester

Guidance literature:: With 4-methyl-morpholine; chloroformic acid ethyl ester; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1021/jm9601516

Reference yield:

: 173305-27-6
2,6-Dichloro-benzoic acid (S)-3-{2-[5-benzyloxycarbonylamino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamino}-4-tert-butoxycarbonyl-2-oxo-butyl ester

: 2,6-Dichloro-benzoic acid (S)-3-{2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamino}-4-tert-butoxycarbonyl-2-oxo-butyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; at 25 ℃; for 3h; under 760 Torr;
DOI:10.1021/jm9601516

Reference yield:

: 173305-27-6
2,6-Dichloro-benzoic acid (S)-3-{2-[5-benzyloxycarbonylamino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamino}-4-tert-butoxycarbonyl-2-oxo-butyl ester

: 2,6-Dichloro-benzoic acid (S)-4-tert-butoxycarbonyl-3-{2-[5-(6-dimethylamino-hexanoylamino)-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamino}-2-oxo-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂, 6M aq. HCl / 10percent Pd/C / ethanol / 3 h / 25 °C / 760 Torr

2: ethyl chloroformate, N-methylmorpholine / tetrahydrofuran / 1 h / 0 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; chloroformic acid ethyl ester; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm9601516