[(2R)-2r-acetylsulfanyl-4-oxo-3c-(2-phenoxy-acetylamino)-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester

Base Information

• Chemical Name: [(2R)-2r-acetylsulfanyl-4-oxo-3c-(2-phenoxy-acetylamino)-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester
• CAS No.: 64370-33-8
• Molecular Formula: C₄₀H₃₄N₃O₈PS
• Molecular Weight: 747.765

Synonyms:[(2R)-2r-acetylsulfanyl-4-oxo-3c-(2-phenoxy-acetylamino)-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester

Chemical Property of [(2R)-2r-acetylsulfanyl-4-oxo-3c-(2-phenoxy-acetylamino)-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(2R)-2r-acetylsulfanyl-4-oxo-3c-(2-phenoxy-acetylamino)-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester

There total 4 articles about [(2R)-2r-acetylsulfanyl-4-oxo-3c-(2-phenoxy-acetylamino)-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(2R,3S)-2-Acetylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-2-enoic acid 4-nitro-benzyl ester (64406-65-1,87069-74-7) → [(2R,3S)-2-Acetylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-(triphenyl-λ5-phosphanylidene)-acetic acid 4-nitro-benzyl ester (64370-33-8,87068-95-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) O₃, 2.) methanol / 1.) CH₂Cl₂, -78 deg C

2: triethylamine / dioxane

3: 1.) 2,6-lutidine, thionyl chloride 2.) silica gel / 1.) THF -30 deg C, 0 deg C, 2.) THF, 15 h

With 2,6-dimethylpyridine; methanol; thionyl chloride; silica gel; ozone; triethylamine; In 1,4-dioxane;

DOI:10.1016/S0040-4039(00)81966-8

Reference yield:

Thioacetic acid S-[(R)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-2-yl] ester (36760-22-2,37004-07-2,87068-92-6) → [(2R,3S)-2-Acetylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-(triphenyl-λ5-phosphanylidene)-acetic acid 4-nitro-benzyl ester (64370-33-8,87068-95-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dioxane

2: 1.) 2,6-lutidine, thionyl chloride 2.) silica gel / 1.) THF -30 deg C, 0 deg C, 2.) THF, 15 h

With 2,6-dimethylpyridine; thionyl chloride; silica gel; triethylamine; In 1,4-dioxane;

DOI:10.1016/S0040-4039(00)81966-8

Reference yield:

[(2R,3S)-2-Acetylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-hydroxy-acetic acid 4-nitro-benzyl ester (64370-37-2,68780-54-1,68780-55-2,87068-93-7,87068-94-8) + triphenylphosphine (603-35-0) → [(2R,3S)-2-Acetylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-(triphenyl-λ5-phosphanylidene)-acetic acid 4-nitro-benzyl ester (64370-33-8,87068-95-9)

Guidance literature:

With 2,6-dimethylpyridine; thionyl chloride; silica gel; Yield given. Multistep reaction; 1.) THF -30 deg C, 0 deg C, 2.) THF, 15 h;

DOI:10.1016/S0040-4039(00)81966-8

upstream raw materials:

[(2R,3S)-2-Acetylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-hydroxy-acetic acid 4-nitro-benzyl ester

triphenylphosphine

2-[(2R,3S)-2-Acetylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-2-enoic acid 4-nitro-benzyl ester

Thioacetic acid S-[(R)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-2-yl] ester

Downstream raw materials:

p-nitrobenzyl 5-methylthiazole-4-carboxylate

(5R)-3-methyl-7-oxo-6t-(2-phenoxy-acetylamino)-(5rH)-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

(5R)-3-methyl-7-oxo-6t-(2-phenoxy-acetylamino)-(5rH)-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid

2-Phenoxymethyl-4H-oxazol-5-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 64370-33-8 [(2R)-2r-acetylsulfanyl-4-oxo-3c-(2-phenoxy-acetylamino)-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send