5-n-butyloxycarbonylamino-4-oxo-6-phenylhexanoyl-L-proline

Base Information

Chemical Name:5-n-butyloxycarbonylamino-4-oxo-6-phenylhexanoyl-L-proline
CAS No.:83084-86-0
Molecular Formula:C₂₂H₃₀N₂O₆
Molecular Weight:418.49
Hs Code.:

Synonyms:5-n-butyloxycarbonylamino-4-oxo-6-phenylhexanoyl-L-proline

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Chemical Property of 5-n-butyloxycarbonylamino-4-oxo-6-phenylhexanoyl-L-proline

Chemical Property:

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Technology Process of 5-n-butyloxycarbonylamino-4-oxo-6-phenylhexanoyl-L-proline

There total 11 articles about 5-n-butyloxycarbonylamino-4-oxo-6-phenylhexanoyl-L-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5874-61-3,21453-79-2,51127-19-6,75658-67-2
4-benzyl-2-phenyl-2-oxazolin-5-one

: 83084-86-0
5-n-butyloxycarbonylamino-4-oxo-6-phenylhexanoyl-L-proline

Guidance literature:: Multi-step reaction with 9 steps

1: Et₃N / tetrahydrofuran / 16 h / Ambient temperature

2: pyridine, HOAc / 1 h / 100 °C

3: 0.5 N aq. NaOH / tetrahydrofuran / 4 h / Ambient temperature

4: 78 percent / conc. aq. HCl, acetic acid / 24 h / Heating

5: HCl / 18 h

6: 0.492 g / Na₂CO₃ / H₂O / 1 h

7: 1N aq. NaOH / methanol / 0.17 h

8: Et₃N, DCC / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) RT, 18 h

9: H₂ / 10percent Pd/C, acetic acid / 16 h / 760 Torr / Ambient temperature

With pyridine; hydrogenchloride; sodium hydroxide; hydrogen; sodium carbonate; acetic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; acetic acid; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm00353a005

Reference yield:

: 77982-73-1
(R,S)-5-benzoylamino-4-oxo-6-phenylhexanoic acid methyl ester

: 83084-86-0
5-n-butyloxycarbonylamino-4-oxo-6-phenylhexanoyl-L-proline

Guidance literature:: Multi-step reaction with 7 steps

1: 0.5 N aq. NaOH / tetrahydrofuran / 4 h / Ambient temperature

2: 78 percent / conc. aq. HCl, acetic acid / 24 h / Heating

3: HCl / 18 h

4: 0.492 g / Na₂CO₃ / H₂O / 1 h

5: 1N aq. NaOH / methanol / 0.17 h

6: Et₃N, DCC / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) RT, 18 h

7: H₂ / 10percent Pd/C, acetic acid / 16 h / 760 Torr / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; sodium carbonate; acetic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; acetic acid; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm00353a005

Reference yield:

: 83084-67-7
2-Phenyl-4-benzyl-4-β-carbomethoxypropionyloxazolone

: 83084-86-0
5-n-butyloxycarbonylamino-4-oxo-6-phenylhexanoyl-L-proline

Guidance literature:: Multi-step reaction with 8 steps

1: pyridine, HOAc / 1 h / 100 °C

2: 0.5 N aq. NaOH / tetrahydrofuran / 4 h / Ambient temperature

3: 78 percent / conc. aq. HCl, acetic acid / 24 h / Heating

4: HCl / 18 h

5: 0.492 g / Na₂CO₃ / H₂O / 1 h

6: 1N aq. NaOH / methanol / 0.17 h

7: Et₃N, DCC / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) RT, 18 h

8: H₂ / 10percent Pd/C, acetic acid / 16 h / 760 Torr / Ambient temperature

With pyridine; hydrogenchloride; sodium hydroxide; hydrogen; sodium carbonate; acetic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; acetic acid; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm00353a005