(3R, 4S)-trans-3-carbomethoxy-4-(4-fluorophenyl)-N-methyl-piperidine

Base Information

• Chemical Name: (3R, 4S)-trans-3-carbomethoxy-4-(4-fluorophenyl)-N-methyl-piperidine
• CAS No.: 335158-56-0
• Molecular Formula: C₁₄H₁₈FNO₂
• Molecular Weight: 251.301
• Mol file: 335158-56-0.mol

Synonyms:(3R, 4S)-trans-3-carbomethoxy-4-(4-fluorophenyl)-N-methyl-piperidine

Chemical Property of (3R, 4S)-trans-3-carbomethoxy-4-(4-fluorophenyl)-N-methyl-piperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R, 4S)-trans-3-carbomethoxy-4-(4-fluorophenyl)-N-methyl-piperidine

There total 2 articles about (3R, 4S)-trans-3-carbomethoxy-4-(4-fluorophenyl)-N-methyl-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (-)-3-[N-methyl-N-(3-methanesulfonyloxy-3-(4-fluoro-phenyl) propyl)] aminopropionate → (3R, 4S)-trans-3-carbomethoxy-4-(4-fluorophenyl)-N-methyl-piperidine (335158-56-0)

Guidance literature:

methyl (-)-3-[N-methyl-N-(3-methanesulfonyloxy-3-(4-fluoro-phenyl) propyl)] aminopropionate; With sodium hydride; In DMF (N,N-dimethyl-formamide); at -15 - 30 ℃; for 21 - 22h;

With water;

Reference yield:

C8H8O3*C14H18FNO2 (859224-60-5) → (3R, 4S)-trans-3-carbomethoxy-4-(4-fluorophenyl)-N-methyl-piperidine (335158-56-0)

Guidance literature:

In water; toluene;

Reference yield:

(3R, 4S)-trans-3-carbomethoxy-4-(4-fluorophenyl)-N-methyl-piperidine (335158-56-0) → (-)-trans-4-(4'-Fluorophenyl)-3-hydroxymethyl-N-methyl-piperidine (389573-45-9)

Guidance literature:

(3R, 4S)-trans-3-carbomethoxy-4-(4-fluorophenyl)-N-methyl-piperidine; With lithium aluminium tetrahydride; In tetrahydrofuran; at -30 - -25 ℃; for 0.5h;

With water; at 25 - 30 ℃; for 1h;

upstream raw materials:

C₈H₈O₃*C₁₄H₁₈FNO₂

Downstream raw materials:

C₈H₈O₃*C₁₄H₁₈FNO₂

(-)-trans-4-(4'-Fluorophenyl)-3-hydroxymethyl-N-methyl-piperidine