dimethyl 5-phenyl-4-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyridazine-3,6-dicarboxylate

Base Information

Chemical Name:dimethyl 5-phenyl-4-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyridazine-3,6-dicarboxylate
CAS No.:949021-87-8
Molecular Formula:C₄₀H₃₈N₂O₈
Molecular Weight:674.75
Hs Code.:

Synonyms:dimethyl 5-phenyl-4-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyridazine-3,6-dicarboxylate

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Chemical Property of dimethyl 5-phenyl-4-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyridazine-3,6-dicarboxylate

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Technology Process of dimethyl 5-phenyl-4-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyridazine-3,6-dicarboxylate

There total 4 articles about dimethyl 5-phenyl-4-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyridazine-3,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 2166-14-5
1,2,4,5-tetrazine-3,6-dicarboxylic acid dimethyl ester

: 113794-29-9
1-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)-2-phenylacetylene

: 949021-87-8
dimethyl 5-phenyl-4-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyridazine-3,6-dicarboxylate

Guidance literature:: In toluene; for 96h; Heating;
DOI:10.1002/ejoc.200700102

Reference yield:

: 935693-86-0
(2R,3R,4S,5S)-1,3,4-tribenzoxy-7-phenylhept-6-yne-2,5-diol

: 949021-87-8
dimethyl 5-phenyl-4-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyridazine-3,6-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / tosyl chloride / pyridine / 3 h / 50 - 60 °C

2: 49 percent / toluene / 96 h / Heating

With p-toluenesulfonyl chloride; In pyridine; toluene;
DOI:10.1002/ejoc.200700102

Reference yield:

: 16838-89-4
2,3,5-tri-O-benzyl-D-ribofuranose

: 949021-87-8
dimethyl 5-phenyl-4-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyridazine-3,6-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -5 - 10 °C

1.2: tetrahydrofuran; hexane / 2 h / 20 °C

2.1: 52 percent / tosyl chloride / pyridine / 3 h / 50 - 60 °C

3.1: 49 percent / toluene / 96 h / Heating

With n-butyllithium; p-toluenesulfonyl chloride; In tetrahydrofuran; pyridine; hexane; toluene;
DOI:10.1002/ejoc.200700102