(S)-1,2,4-TRITOSYL BUTANETRIOL

Base Information

• Chemical Name: (S)-1,2,4-TRITOSYL BUTANETRIOL
• CAS No.: 99520-83-9
• Molecular Formula: C25H28O9S3
• Molecular Weight: 568.68
• Hs Code.: 2905199090
• Mol file: 99520-83-9.mol

Synonyms:(-)-(S)-butane-1,2,4-triyl tris(p-toluenesulfonate);1H-1,4-Benzodiazepine-1-carbothioamide,7-chloro-4-(cyclopropylmethyl)-2,3,4,5-tetrahydro-N,3-dimethyl-,(3S)-,(2Z)-2-butenedioate (1:1);(3S)-7-chloro-4-(cyclopropylmethyl)-N,3-dimethyl-3,5-dihydro-2H-1,4-benzodiazepine-1-carbothioamide;(-)-(S)-7-chloro-4-(cyclopropylmethyl)-2,3,4,5-tetrahydro-N,3-dimethyl-1H-1,4-benzodiazepine-1-carbothioamide (Z)-2-butanedioate (1:1);

Chemical Property of (S)-1,2,4-TRITOSYL BUTANETRIOL

Chemical Property:

• PSA: 155.25000
• LogP: 7.12920

Purity/Quality:

98%Min ^*data from raw suppliers

(S)-1,2,4-TRITOSYLBUTANETRIOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1,2,4-TRITOSYL BUTANETRIOL

There total 2 articles about (S)-1,2,4-TRITOSYL BUTANETRIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(S)-1,2,4-butanetriol (42890-76-6,6810-31-7) + p-toluenesulfonyl chloride (98-59-9) → (-)-(S)-butane-1,2,4-triyl tris(p-toluenesulfonate) (99520-83-9)

Guidance literature:

With pyridine; at -20 ℃; for 20h;

DOI:10.1055/s-1989-27368

Reference yield:

(S)-1,2,4-butanetriol (42890-76-6,6810-31-7) + hypochlorous acid 4-methylbenzene sulfonic anhydride (103057-51-8) → (-)-(S)-butane-1,2,4-triyl tris(p-toluenesulfonate) (99520-83-9)

Guidance literature:

In pyridine; at 0 - 5 ℃;

DOI:10.1002/hlca.19890720520

Reference yield: 63.0%

(-)-(S)-butane-1,2,4-triyl tris(p-toluenesulfonate) (99520-83-9) + lithium diphenylphosphide (65567-06-8,4541-02-0) → (R)-(+)-1,2,4-tris(diphenylphosphanyl)butane (124128-36-5)

Guidance literature:

In tetrahydrofuran; for 20h; Ambient temperature;

DOI:10.1055/s-1989-27368

upstream raw materials:

(S)-1,2,4-butanetriol

hypochlorous acid 4-methylbenzene sulfonic anhydride

p-toluenesulfonyl chloride

Downstream raw materials:

(R)-(+)-1,2,4-tris(diphenylphosphanyl)butane

Refernces

• 1、 Brunner, Henri,Lautenschlager, Hans-Juergen. "Synthesis of New Optically Active Bis- and Tris(phosphines)". . p. 706 - 709. Retrieved 2007/10/02.