<1R-(endo,endo)>-3-Hydroxy-4,7,7-trimethylbicyclo<2.2.1>heptan-2-methanol,4-Methylbenzolsulfonat

Base Information

• Chemical Name: <1R-(endo,endo)>-3-Hydroxy-4,7,7-trimethylbicyclo<2.2.1>heptan-2-methanol,4-Methylbenzolsulfonat
• CAS No.: 81969-26-8
• Molecular Formula: C₁₈H₂₆O₄S
• Molecular Weight: 338.468
• Mol file: 81969-26-8.mol

Synonyms:<1R-(endo,endo)>-3-Hydroxy-4,7,7-trimethylbicyclo<2.2.1>heptan-2-methanol,4-Methylbenzolsulfonat

Chemical Property of <1R-(endo,endo)>-3-Hydroxy-4,7,7-trimethylbicyclo<2.2.1>heptan-2-methanol,4-Methylbenzolsulfonat

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <1R-(endo,endo)>-3-Hydroxy-4,7,7-trimethylbicyclo<2.2.1>heptan-2-methanol,4-Methylbenzolsulfonat

There total 7 articles about <1R-(endo,endo)>-3-Hydroxy-4,7,7-trimethylbicyclo<2.2.1>heptan-2-methanol,4-Methylbenzolsulfonat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R)-3endo-hydroxy-4,7,7-trimethyl-norbornane-2endo-carboxylic acid (4572-70-7,6088-75-1,6246-41-9,24398-96-7,63976-52-3,63976-57-8,63976-58-9,63976-59-0) → <1R-(endo,endo)>-3-Hydroxy-4,7,7-trimethylbicyclo<2.2.1>heptan-2-methanol,4-Methylbenzolsulfonat (81969-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄; diethyl ether

With lithium aluminium tetrahydride; diethyl ether;

Reference yield:

(1R)-3endo-hydroxy-4,7,7-trimethyl-norbornane-2endo-carboxylic acid methyl ester → <1R-(endo,endo)>-3-Hydroxy-4,7,7-trimethylbicyclo<2.2.1>heptan-2-methanol,4-Methylbenzolsulfonat (81969-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄; diethyl ether

With lithium aluminium tetrahydride; diethyl ether;

Reference yield:

(+)-4,7,7-trimethyl-3-oxobicyclo<2.2.1>heptane-endo-2-carboxylic acid (18530-30-8) + p-toluenesulfonyl chloride (98-59-9) → <1R-(endo,endo)>-3-Hydroxy-4,7,7-trimethylbicyclo<2.2.1>heptan-2-methanol,4-Methylbenzolsulfonat (81969-26-8) + <1R-(exo,exo)>-3-Hydroxy-4,7,7-trimethylbicyclo<2.2.1>heptan-2-methanol,4-Methylbenzolsulfonat + <1R-(endo,exo)>-3-Hydroxy-4,7,7-trimethylbicyclo<2.2.1>heptan-2-methanol,4-Methylbenzolsulfonat (24399-00-6,24399-07-3,81969-26-8,81969-27-9,111766-16-6)

Guidance literature:

With pyridine; sodium tetrahydroborate; boron trifluoride diethyl etherate; Yield given. Multistep reaction. Yields of byproduct given; 1) THF, 17 h, 25 deg C, 2) CH₂Cl₂, 5 h, r.t.;

upstream raw materials:

p-toluenesulfonyl chloride

(1R,4S)-3-(hydroxymethylene)-1,7,7-trimethylbicyclo-[2.2.1]heptan-2-one

(+)-4,7,7-trimethyl-3-oxobicyclo<2.2.1>heptane-endo-2-carboxylic acid

(1R)-3endo-hydroxy-4,7,7-trimethyl-norbornane-2endo-carboxylic acid

Downstream raw materials:

(1R,2S,4S,6S,7R)-4-Benzhydryloxy-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]decane

<2R-(2α,3aα,4α,7α,7aα)>-2,3,3a,4,5,6,7,7a-Octahydro-2-(1,1-diphenylmethoxy)-7,8,8-trimethyl-4,7-methanobenzofuran

(1R,2S,4R,6S,7R)-4-Cyclohexyloxy-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]decane

<2S-(2α,3aα,4α,7α,7aα)>-2,3,3a,4,5,6,7,7a-Octahydro-2-cyclohexyloxy-7,8,8-trimethyl-4,7-methanobenzofuran