3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]propan-1-ol

Base Information

Chemical Name:3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]propan-1-ol
CAS No.:133008-08-9
Molecular Formula:C8H16O3
Molecular Weight:160.21
Hs Code.:2932999099
DSSTox Substance ID:DTXSID70448319
Nikkaji Number:J1.189.876I
Wikidata:Q82267292
Mol file:133008-08-9.mol

Synonyms:133008-08-9;3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]propan-1-ol;(R)-3-(2,2-Dimethyl-1,3-dioxolan-4-yl)propan-1-ol;(R)-2,2-dimethyl-1,3-dioxolane-4-propanol;1,3-Dioxolane-4-propanol, 2,2-dimethyl-, (4R)-;(R )-2,2-DIMETHYL-1,3-DIOXOLANE-4-PROPANOL;SCHEMBL1243925;DTXSID70448319;BSLDYXOPGSOQGZ-SSDOTTSWSA-N;(R)-4,5-Isopropylidene-1-pentanol;AKOS006279408;AC-11083;(R)-2,2-Dimethyl-1,3-dioxolane-4alpha-(1-propanol)

Suppliers and Price of 3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]propan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(R)-2,2-DIMETHYL-1,3-DIOXOLANE-4-PROPANOL 95.00%
5MG
$ 500.72

Total 12 raw suppliers

Chemical Property of 3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]propan-1-ol

Chemical Property:

Vapor Pressure:0.023mmHg at 25°C
Refractive Index:1.434
Boiling Point:221.017 °C at 760 mmHg
Flash Point:103.746 °C
PSA：38.69000
Density:0.996 g/cm³
LogP:0.91040
XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:160.109944368
Heavy Atom Count:11
Complexity:123

Purity/Quality:

99% ^*data from raw suppliers

(R)-2,2-DIMETHYL-1,3-DIOXOLANE-4-PROPANOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 37/38-41-43
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(OCC(O1)CCCO)C
Isomeric SMILES:CC1(OC[C@H](O1)CCCO)C

Technology Process of 3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]propan-1-ol

There total 10 articles about 3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 173152-84-6
ethyl (R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propionate

: 133008-08-9
(4R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.tetasy.2005.01.045

Reference yield: 92.0%

: 133494-69-6
(R)-4-but-3-enyl-2,2-dimethyl[1,3]dioxolane

: 133008-08-9
(4R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propan-1-ol

Guidance literature:: (R)-4-but-3-enyl-2,2-dimethyl[1,3]dioxolane; With potassium carbonate; ozone; In methanol; dichloromethane; at -78 ℃;

With sodium tetrahydroborate; In methanol; dichloromethane; at -78 - 20 ℃;
DOI:10.1021/ol050567q

Reference yield:

: 22323-80-4
(4S)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde

: 133008-08-9
(4R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 9 h / 20 °C

2: H₂ / PtO₂ / ethyl acetate / 4 h / 20 °C

3: LiAlH₄ / tetrahydrofuran / 3 h / 20 °C

With lithium aluminium tetrahydride; hydrogen; platinum(IV) oxide; In tetrahydrofuran; dichloromethane; ethyl acetate; 1: Wittig olefination;
DOI:10.1016/j.tetasy.2005.01.044