3-[(2S,4S)-1-tert-butoxycarbonyl-4-(3,4-dicyanophenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine

Base Information

Chemical Name:3-[(2S,4S)-1-tert-butoxycarbonyl-4-(3,4-dicyanophenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine
CAS No.:401565-01-3
Molecular Formula:C₂₁H₂₅N₅O₃S
Molecular Weight:427.527
Hs Code.:

Synonyms:3-[(2S,4S)-1-tert-butoxycarbonyl-4-(3,4-dicyanophenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine

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Chemical Property of 3-[(2S,4S)-1-tert-butoxycarbonyl-4-(3,4-dicyanophenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine

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Technology Process of 3-[(2S,4S)-1-tert-butoxycarbonyl-4-(3,4-dicyanophenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine

There total 5 articles about 3-[(2S,4S)-1-tert-butoxycarbonyl-4-(3,4-dicyanophenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 401564-31-6
3-((2S,4S)-4-amino-1-tert-butoxycarbonyl-2-pyrrolidinylcarbonyl)-1,3-thiazolidine

: 65610-14-2
4-fluorophthalonitrile

: 401565-01-3
3-[(2S,4S)-1-tert-butoxycarbonyl-4-(3,4-dicyanophenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 4h;
DOI:10.1016/j.bmc.2006.01.022

Reference yield:

: 401564-30-5
3-[(2S,4R)-1-tert-butoxycarbonyl-4-hydroxy-2-pyrrolidinylcarbonyl]-1,3-thiazolidine

: 401565-01-3
3-[(2S,4S)-1-tert-butoxycarbonyl-4-(3,4-dicyanophenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: 39.5 g / NaN₃ / dimethylformamide / 5 h / 80 °C

3: H₂ / Pd/C / ethanol / 18 h / 20 °C / 760 Torr

4: 1.08 g / diisopropylethylamine / 1-methyl-pyrrolidin-2-one / 4 h / 80 °C

With sodium azide; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.01.022

Reference yield:

: 401564-33-8
3-((2S,4S)-4-azido-1-tert-butoxycarbonyl-2-pyrrolidinylcarbonyl)-1,3-thiazolidine

: 401565-01-3
3-[(2S,4S)-1-tert-butoxycarbonyl-4-(3,4-dicyanophenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethanol / 18 h / 20 °C / 760 Torr

2: 1.08 g / diisopropylethylamine / 1-methyl-pyrrolidin-2-one / 4 h / 80 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; ethanol;
DOI:10.1016/j.bmc.2006.01.022