[(S)-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-(3-hydroxy-phenyl)-ethylcarbamoyl]-(3-isopropoxy-phenyl)-methyl]-carbamic acid tert-butyl ester

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Chemical Name:[(S)-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-(3-hydroxy-phenyl)-ethylcarbamoyl]-(3-isopropoxy-phenyl)-methyl]-carbamic acid tert-butyl ester
CAS No.:173775-52-5
Molecular Formula:C₃₀H₄₆N₂O₆Si
Molecular Weight:558.791
Hs Code.:

Synonyms:[(S)-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-(3-hydroxy-phenyl)-ethylcarbamoyl]-(3-isopropoxy-phenyl)-methyl]-carbamic acid tert-butyl ester

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Chemical Property of [(S)-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-(3-hydroxy-phenyl)-ethylcarbamoyl]-(3-isopropoxy-phenyl)-methyl]-carbamic acid tert-butyl ester

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Technology Process of [(S)-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-(3-hydroxy-phenyl)-ethylcarbamoyl]-(3-isopropoxy-phenyl)-methyl]-carbamic acid tert-butyl ester

There total 14 articles about [(S)-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-(3-hydroxy-phenyl)-ethylcarbamoyl]-(3-isopropoxy-phenyl)-methyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 173775-51-4
[(S)-[(R)-1-(3-Allyloxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethylcarbamoyl]-(3-isopropoxy-phenyl)-methyl]-carbamic acid tert-butyl ester

: 173775-52-5
[(S)-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-(3-hydroxy-phenyl)-ethylcarbamoyl]-(3-isopropoxy-phenyl)-methyl]-carbamic acid tert-butyl ester

Guidance literature:: With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾;
DOI:10.1016/0040-4039(95)01876-J

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 173775-52-5
[(S)-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-(3-hydroxy-phenyl)-ethylcarbamoyl]-(3-isopropoxy-phenyl)-methyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / H₂ / Pd/C / ethyl acetate / 2 h / 760 Torr

2: 92 percent / LiOH / tetrahydrofuran; H₂O

3: 92 percent / EDC, HOBt / CH₂Cl₂ / 0.5 h / 0 °C

4: 85 percent / NaBH₄, Pd(PPh₃)4 / tetrahydrofuran / 1 h / Ambient temperature

With lithium hydroxide; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; ethyl acetate;
DOI:10.1021/jo961412m

Reference yield:

: C₁₆H₂₂O₄

: 173775-52-5
[(S)-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-(3-hydroxy-phenyl)-ethylcarbamoyl]-(3-isopropoxy-phenyl)-methyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / Et₃N / tetrahydrofuran / 0.25 h / -78 °C

2: 1.) KHDMS, 2.) trisyl azide / 1.) THF_. -78 deh C, 30 min, 2.) THF, -78 deg C, 4 min

3: 92 percent / H₂ / Pd/C / ethyl acetate / 2 h / 760 Torr

4: 92 percent / LiOH / tetrahydrofuran; H₂O

5: 92 percent / EDC, HOBt / CH₂Cl₂ / 0.5 h / 0 °C

6: 85 percent / NaBH₄, Pd(PPh₃)4 / tetrahydrofuran / 1 h / Ambient temperature

With lithium hydroxide; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; potassium hexamethylsilazane; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; ethyl acetate;
DOI:10.1021/jo961412m