(+/-)-2-(N-tert-butylamino)-4'-aminopropiophenone

Base Information

• Chemical Name: (+/-)-2-(N-tert-butylamino)-4'-aminopropiophenone
• CAS No.: 104657-22-9
• Molecular Formula: C₁₃H₂₀N₂O
• Molecular Weight: 220.315
• Mol file: 104657-22-9.mol

Synonyms:(+/-)-2-(N-tert-butylamino)-4'-aminopropiophenone

Chemical Property of (+/-)-2-(N-tert-butylamino)-4'-aminopropiophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-2-(N-tert-butylamino)-4'-aminopropiophenone

There total 5 articles about (+/-)-2-(N-tert-butylamino)-4'-aminopropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(+/-)-2-(N-tert-butylamino)-4'-N-acetylaminopropiophenone hydrochloride → (+/-)-2-(N-tert-butylamino)-4'-aminopropiophenone (104657-22-9)

Guidance literature:

With hydrogenchloride; water; Reflux;

DOI:10.1016/j.bmcl.2011.10.086

Reference yield:

1-(4-acetylaminophenyl)-2-tert.-butylaminopropanone (97110-67-3) → (+/-)-2-(N-tert-butylamino)-4'-aminopropiophenone (104657-22-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / diethyl ether

2: hydrogenchloride; water / Reflux

With hydrogenchloride; water; In diethyl ether;

DOI:10.1016/j.bmcl.2011.10.086

Reference yield:

1-(4-aminophenyl)-1-propanone (70-69-9) → (+/-)-2-(N-tert-butylamino)-4'-aminopropiophenone (104657-22-9)

Guidance literature:

Multi-step reaction with 5 steps

1: ethyl acetate / 2.5 h / 0 - 80 °C

2: bromine / chloroform / 3 h / 55 °C

3: 1-methyl-pyrrolidin-2-one / 0.17 h / 55 °C

4: hydrogenchloride / diethyl ether

5: hydrogenchloride; water / Reflux

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; water; bromine; In diethyl ether; chloroform; ethyl acetate;

DOI:10.1016/j.bmcl.2011.10.086

upstream raw materials:

1-(4-acetylaminophenyl)-2-tert.-butylaminopropanone

N-(4-propionylphenyl)acetamide

1-(4-aminophenyl)-1-propanone

N-(4-(2-bromopropionyl)phenyl)acetamide

Refernces