6-chloro-2-fluoro-3-(pivalamidomethyl)-N-(1-((3-(trifluoromethyl)phenyl)amino)isoquinolin-5-yl)benzamide

Base Information

Chemical Name:6-chloro-2-fluoro-3-(pivalamidomethyl)-N-(1-((3-(trifluoromethyl)phenyl)amino)isoquinolin-5-yl)benzamide
CAS No.:1449735-79-8
Molecular Formula:C₂₉H₂₅ClF₄N₄O₂
Molecular Weight:572.99
Hs Code.:

Synonyms:6-chloro-2-fluoro-3-(pivalamidomethyl)-N-(1-((3-(trifluoromethyl)phenyl)amino)isoquinolin-5-yl)benzamide

Suppliers and Price of 6-chloro-2-fluoro-3-(pivalamidomethyl)-N-(1-((3-(trifluoromethyl)phenyl)amino)isoquinolin-5-yl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-chloro-2-fluoro-3-(pivalamidomethyl)-N-(1-((3-(trifluoromethyl)phenyl)amino)isoquinolin-5-yl)benzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6-chloro-2-fluoro-3-(pivalamidomethyl)-N-(1-((3-(trifluoromethyl)phenyl)amino)isoquinolin-5-yl)benzamide

There total 10 articles about 6-chloro-2-fluoro-3-(pivalamidomethyl)-N-(1-((3-(trifluoromethyl)phenyl)amino)isoquinolin-5-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1449736-68-8
N-(3-(trifluoromethyl)phenyl)isoquinoline-1,5-diamine

: C₁₃H₁₄Cl₂FNO₂

: 1449735-79-8
6-chloro-2-fluoro-3-(pivalamidomethyl)-N-(1-((3-(trifluoromethyl)phenyl)amino)isoquinolin-5-yl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 26 ℃; for 2h;

Reference yield:

: 773134-56-8
ethyl 2-chloro-6-fluorobenzoate

: 1449735-79-8
6-chloro-2-fluoro-3-(pivalamidomethyl)-N-(1-((3-(trifluoromethyl)phenyl)amino)isoquinolin-5-yl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -78 °C

1.2: 2 h / -78 - 0 °C

2.1: hydroxylamine / water; methanol / 1.5 h / 55 °C

3.1: hydrogenchloride; zinc / ethanol; methanol / 21 h / 22 - 26 °C / Reflux

4.1: triethylamine / tetrahydrofuran / 2 h / 22 - 26 °C

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 22 - 26 °C

6.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 2 h / 22 - 26 °C

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 26 °C

With hydrogenchloride; n-butyllithium; oxalyl dichloride; water; hydroxylamine; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; zinc; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1294496-84-6
ethyl 6-chloro-2-fluoro-3-formylbenzoate

: 1449735-79-8
6-chloro-2-fluoro-3-(pivalamidomethyl)-N-(1-((3-(trifluoromethyl)phenyl)amino)isoquinolin-5-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: hydroxylamine / water; methanol / 1.5 h / 55 °C

2: hydrogenchloride; zinc / ethanol; methanol / 21 h / 22 - 26 °C / Reflux

3: triethylamine / tetrahydrofuran / 2 h / 22 - 26 °C

4: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 22 - 26 °C

5: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 2 h / 22 - 26 °C

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 26 °C

With hydrogenchloride; oxalyl dichloride; water; hydroxylamine; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;