(3R)-1-[(R)-1-carboxyethyl]-3-methyl-3-(2-nitrobenzenesulfonylamino)azetidin-2-one

Base Information

Chemical Name:(3R)-1-[(R)-1-carboxyethyl]-3-methyl-3-(2-nitrobenzenesulfonylamino)azetidin-2-one
CAS No.:1415380-02-7
Molecular Formula:C₁₃H₁₅N₃O₇S
Molecular Weight:357.344
Hs Code.:

Synonyms:(3R)-1-[(R)-1-carboxyethyl]-3-methyl-3-(2-nitrobenzenesulfonylamino)azetidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R)-1-[(R)-1-carboxyethyl]-3-methyl-3-(2-nitrobenzenesulfonylamino)azetidin-2-one

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Technology Process of (3R)-1-[(R)-1-carboxyethyl]-3-methyl-3-(2-nitrobenzenesulfonylamino)azetidin-2-one

There total 4 articles about (3R)-1-[(R)-1-carboxyethyl]-3-methyl-3-(2-nitrobenzenesulfonylamino)azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 1415380-02-7
(3R)-1-[(R)-1-carboxyethyl]-3-methyl-3-(2-nitrobenzenesulfonylamino)azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydrogencarbonate / acetonitrile / 16 h / Inert atmosphere; Reflux

2: acetonitrile / 20 h / 20 °C / Inert atmosphere

3: lithium hexamethyldisilazane / tetrahydrofuran / 12 h / Inert atmosphere

4: [bis(acetoxy)iodo]benzene; 2,2,6,6-tetramethyl-piperidine-N-oxyl / acetone; water / 3 h / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene; potassium hydrogencarbonate; lithium hexamethyldisilazane; In tetrahydrofuran; water; acetone; acetonitrile;
DOI:10.1021/jo302368y

Reference yield:

: 923578-98-7
(2R)-2-methyl-2-methoxycarbonyl-1-(2-nitrobenzenesulfonyl)-aziridine

: 1415380-02-7
(3R)-1-[(R)-1-carboxyethyl]-3-methyl-3-(2-nitrobenzenesulfonylamino)azetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 20 h / 20 °C / Inert atmosphere

2: lithium hexamethyldisilazane / tetrahydrofuran / 12 h / Inert atmosphere

3: [bis(acetoxy)iodo]benzene; 2,2,6,6-tetramethyl-piperidine-N-oxyl / acetone; water / 3 h / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene; lithium hexamethyldisilazane; In tetrahydrofuran; water; acetone; acetonitrile;
DOI:10.1021/jo302368y

Reference yield:

: C₁₃H₁₇N₃O₆S

: 1415380-02-7
(3R)-1-[(R)-1-carboxyethyl]-3-methyl-3-(2-nitrobenzenesulfonylamino)azetidin-2-one

Guidance literature:: With 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene; In water; acetone; for 3h; Inert atmosphere;
DOI:10.1021/jo302368y