Technology Process of methyl 2-diazo-2-[4-(4'-nitrophenyl)-butylsulfonyl]acetate
There total 5 articles about methyl 2-diazo-2-[4-(4'-nitrophenyl)-butylsulfonyl]acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 2-[4-(4'-nitrophenyl)-butylsulfonyl]acetate;
With
potassium carbonate;
In
acetonitrile;
at 0 ℃;
for 0.166667h;
With
4-toluenesulfonyl azide;
In
acetonitrile;
at 0 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triphenylphosphine; carbon tetrabromide / acetonitrile / 1 h / 20 °C
2.1: potassium carbonate / acetone / 0.25 h
2.2: 17 h / Reflux
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C
4.1: potassium carbonate; 4-toluenesulfonyl azide / acetonitrile / 2.5 h / 0 - 20 °C / Inert atmosphere
With
4-toluenesulfonyl azide; carbon tetrabromide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
In
dichloromethane; acetone; acetonitrile;
DOI:10.1002/ejoc.201800077
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dimethylsulfide borane complex / tetrahydrofuran / 1 h / 20 °C
2.1: triphenylphosphine; carbon tetrabromide / acetonitrile / 1 h / 20 °C
3.1: potassium carbonate / acetone / 0.25 h
3.2: 17 h / Reflux
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C
5.1: potassium carbonate; 4-toluenesulfonyl azide / acetonitrile / 2.5 h / 0 - 20 °C / Inert atmosphere
With
4-toluenesulfonyl azide; carbon tetrabromide; dimethylsulfide borane complex; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; acetone; acetonitrile;
DOI:10.1002/ejoc.201800077