2-(3-(1,3-dioxoisoindolin-2-yl)benzo[d]isoxazol-6-ylamino)-2-oxo-1-(4'-(trifluoromethoxy)biphenyl-3-yl)ethyl acetate

Base Information

Chemical Name:2-(3-(1,3-dioxoisoindolin-2-yl)benzo[d]isoxazol-6-ylamino)-2-oxo-1-(4'-(trifluoromethoxy)biphenyl-3-yl)ethyl acetate
CAS No.:1418267-60-3
Molecular Formula:C₃₂H₂₀F₃N₃O₇
Molecular Weight:615.522
Hs Code.:

Synonyms:2-(3-(1,3-dioxoisoindolin-2-yl)benzo[d]isoxazol-6-ylamino)-2-oxo-1-(4'-(trifluoromethoxy)biphenyl-3-yl)ethyl acetate

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Chemical Property of 2-(3-(1,3-dioxoisoindolin-2-yl)benzo[d]isoxazol-6-ylamino)-2-oxo-1-(4'-(trifluoromethoxy)biphenyl-3-yl)ethyl acetate

Chemical Property:

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Technology Process of 2-(3-(1,3-dioxoisoindolin-2-yl)benzo[d]isoxazol-6-ylamino)-2-oxo-1-(4'-(trifluoromethoxy)biphenyl-3-yl)ethyl acetate

There total 5 articles about 2-(3-(1,3-dioxoisoindolin-2-yl)benzo[d]isoxazol-6-ylamino)-2-oxo-1-(4'-(trifluoromethoxy)biphenyl-3-yl)ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1418267-53-4
2-acetoxy-2-( 4'-(trifluoromethoxy)biphenyl-3-yl)acetic acid

: 1269519-20-1
2-(6-aminobenzo[d]isoxazol-3-yl)isoindoline-1,3-dione

: 1418267-60-3
2-(3-(1,3-dioxoisoindolin-2-yl)benzo[d]isoxazol-6-ylamino)-2-oxo-1-(4'-(trifluoromethoxy)biphenyl-3-yl)ethyl acetate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 0 - 20 ℃;

Reference yield:

: 1418267-50-1
2-acetoxy-2-(3-bromophenyl)acetic acid

: 1418267-60-3
2-(3-(1,3-dioxoisoindolin-2-yl)benzo[d]isoxazol-6-ylamino)-2-oxo-1-(4'-(trifluoromethoxy)biphenyl-3-yl)ethyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 5 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / acetonitrile; water / 0.5 h / 130 °C / Microwave irradiation

3: trifluoroacetic acid / water; dichloromethane / 4 h / 20 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0 - 20 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1418267-51-2
tert-butyl 2-acetoxy-2-(3-bromophenyl)acetate

: 1418267-60-3
2-(3-(1,3-dioxoisoindolin-2-yl)benzo[d]isoxazol-6-ylamino)-2-oxo-1-(4'-(trifluoromethoxy)biphenyl-3-yl)ethyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / acetonitrile; water / 0.5 h / 130 °C / Microwave irradiation

2: trifluoroacetic acid / water; dichloromethane / 4 h / 20 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0 - 20 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; water; acetonitrile;