2-(4-(tert-butyl)-2-{2-[5-(tert-butyl)-2-hydroxyphenyl]-1-ethynyl}phenoxy)-1-ethanol

Base Information

Chemical Name:2-(4-(tert-butyl)-2-{2-[5-(tert-butyl)-2-hydroxyphenyl]-1-ethynyl}phenoxy)-1-ethanol
CAS No.:196106-25-9
Molecular Formula:C₂₄H₃₀O₃
Molecular Weight:366.5
Hs Code.:

Synonyms:2-(4-(tert-butyl)-2-{2-[5-(tert-butyl)-2-hydroxyphenyl]-1-ethynyl}phenoxy)-1-ethanol

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Chemical Property of 2-(4-(tert-butyl)-2-{2-[5-(tert-butyl)-2-hydroxyphenyl]-1-ethynyl}phenoxy)-1-ethanol

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Technology Process of 2-(4-(tert-butyl)-2-{2-[5-(tert-butyl)-2-hydroxyphenyl]-1-ethynyl}phenoxy)-1-ethanol

There total 7 articles about 2-(4-(tert-butyl)-2-{2-[5-(tert-butyl)-2-hydroxyphenyl]-1-ethynyl}phenoxy)-1-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 196106-32-8
C₃₄H₄₆O₅

: 196106-25-9
2-(4-(tert-butyl)-2-{2-[5-(tert-butyl)-2-hydroxyphenyl]-1-ethynyl}phenoxy)-1-ethanol

Guidance literature:: With methanol; pyridinium p-toluenesulfonate; at 50 ℃; for 12h;
DOI:10.1016/S0040-4020(97)00761-8

Reference yield:

: 98-54-4
para-tert-butylphenol

: 196106-25-9
2-(4-(tert-butyl)-2-{2-[5-(tert-butyl)-2-hydroxyphenyl]-1-ethynyl}phenoxy)-1-ethanol

Guidance literature:: Multi-step reaction with 6 steps

1: 61 percent / sodium hypochlorite; potassium hydroxide; sodium iodide / H₂O; methanol / 51 h

2: 96 percent / pyridinium p-toluenesulfonate / 12 h / 50 °C

3: 100 percent / triphenylphosphine; copper(I) iodide / Pd(PPh₃)4 / triethylamine / 3 h / 20 °C

4: 99 percent / potassium hydroxide / CH₂Cl₂; methanol / 4 h / 20 °C

5: 95 percent / triphenylphosphine; copper(I) iodide / Pd(PPh₃)4 / triethylamine / 5 h / 70 °C

6: 92 percent / pyridinium p-toluenesulfonate; methanol / 12 h / 50 °C

With methanol; potassium hydroxide; sodium hypochlorite; copper(l) iodide; pyridinium p-toluenesulfonate; triphenylphosphine; sodium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; water; triethylamine; 1: Iodination / 2: Addition / 3: Arylation / 4: desilylation / 5: Arylation / 6: methanolysis;
DOI:10.1016/S0040-4020(97)00761-8

Reference yield:

: 38941-98-9
4-tert-butyl-2-iodophenol

: 196106-25-9
2-(4-(tert-butyl)-2-{2-[5-(tert-butyl)-2-hydroxyphenyl]-1-ethynyl}phenoxy)-1-ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / pyridinium p-toluenesulfonate / 12 h / 50 °C

2: 100 percent / triphenylphosphine; copper(I) iodide / Pd(PPh₃)4 / triethylamine / 3 h / 20 °C

3: 99 percent / potassium hydroxide / CH₂Cl₂; methanol / 4 h / 20 °C

4: 95 percent / triphenylphosphine; copper(I) iodide / Pd(PPh₃)4 / triethylamine / 5 h / 70 °C

5: 92 percent / pyridinium p-toluenesulfonate; methanol / 12 h / 50 °C

With methanol; potassium hydroxide; copper(l) iodide; pyridinium p-toluenesulfonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; triethylamine; 1: Addition / 2: Arylation / 3: desilylation / 4: Arylation / 5: methanolysis;
DOI:10.1016/S0040-4020(97)00761-8