9-KETO FLUPROSTENOL

Base Information

• Chemical Name: 9-KETO FLUPROSTENOL
• CAS No.: 156406-33-6
• Molecular Formula: C23H27 F3 O6
• Molecular Weight: 456.45
• Mol file: 156406-33-6.mol

Synonyms:FLUPROSTENOL PROSTAGLANDIN E2;9-OXO-11ALPHA,15R-DIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR PROSTA-5Z,13E-DIEN-1-OIC ACID;9-KETO FLUPROSTENOL

Chemical Property of 9-KETO FLUPROSTENOL

Chemical Property:

• PSA: 104.06000
• LogP: 3.76860

Purity/Quality:

99% ^*data from raw suppliers

9-keto Fluprostenol ≥95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: 9-keto Fluprostenol is an analog of prostaglandin E2 (PGE2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor. Oxidation at C-9 of fluprostenol yields 9-keto fluprostenol. It is anticipated that this analog will have strong affinity for EP receptors and act as a PGE2 agonist. However, no studies on the pharmacology of 9-KETO FLUPROSTENOL have been published to date.
• Uses: 9-keto Fluprostenol is an analog of prostaglandin E2 (PGE2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor. Oxidation at C-9 of fluprostenol yields 9-keto fluprostenol. It is anticipated that this analog will have strong affinity for EP receptors and act as a PGE2 agonist. However, no studies on the pharmacology of 9-KETO FLUPROSTENOL have been published to date. 9-Keto Fluprostenol is an impurity of Fluprostenol (F500753), a FP prostaglandin receptor.

Technology Process of 9-KETO FLUPROSTENOL

There total 1 articles about 9-KETO FLUPROSTENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (Z)-7-((1R,2R,3R)-3-hydroxy-2-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoic acid (156406-33-6)

Guidance literature:

Reference yield:

(Z)-7-((1R,2R,3R)-3-hydroxy-2-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoic acid (156406-33-6) → 4-(3-(((1R,2R,3R)-3-hydroxy-2-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)butan-1-ene-1-yl)-5-oxocyclopentyl)methyl)oxiran-2-yl)butyric acid + (Ζ)-7-((1R,2R,3R)-3-hydroxy-2-((2R)-3-((S)-1-hydroxy-2-(3-(trifluoromethyl)phenoxy)ethyl)oxiran-2-yl)-5-oxocyclopentyl)hept-5-enoic acid + 4-(3-{[(1R,2R,3R)-3-hydroxy-2-[(2R)-3-[(S)-1-hydroxy-2-[3-(trifluoromethyl)phenoxy]ethyl]oxiran-2-yl]-5-oxocyclopentyl]methyl}oxiran-2-yl)butanoic acid

Guidance literature:

With peracetic acid; In N,N-dimethyl-formamide; at 55 - 75 ℃;