6-methyl-1-{1-[cis-3-(propyloxy)cyclohexyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one hydrochloride

Base Information

Chemical Name:6-methyl-1-{1-[cis-3-(propyloxy)cyclohexyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one hydrochloride
CAS No.:1067908-05-7
Molecular Formula:C₂₂H₃₃N₃O₂*ClH
Molecular Weight:407.984
Hs Code.:

Synonyms:6-methyl-1-{1-[cis-3-(propyloxy)cyclohexyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one hydrochloride

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Chemical Property of 6-methyl-1-{1-[cis-3-(propyloxy)cyclohexyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one hydrochloride

Chemical Property:

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Technology Process of 6-methyl-1-{1-[cis-3-(propyloxy)cyclohexyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one hydrochloride

There total 17 articles about 6-methyl-1-{1-[cis-3-(propyloxy)cyclohexyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-methyl-1-{1-[cis-3-(propyloxy)cyclohexyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one hydrochloride

: 1067908-05-7
6-methyl-1-{1-[cis-3-(propyloxy)cyclohexyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one hydrochloride

: 1067908-07-9
6-methyl-1-{1-[cis-3-(propyloxy)cyclohexyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one hydrochloride

Guidance literature:: With Chiracel OJ column; In methanol; carbon dioxide; Resolution of racemate;

Reference yield:

: 1-(cis-3-propoxycyclohexyl)-4-piperidone

: 1067908-05-7
6-methyl-1-{1-[cis-3-(propyloxy)cyclohexyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one hydrochloride

: 1067908-07-9
6-methyl-1-{1-[cis-3-(propyloxy)cyclohexyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: ammonia; hydrogen / palladium 10% on activated carbon / methanol / 24 h / 2844.39 Torr

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 200 °C / microwave reactor

3: hydrazine / nickel / ethanol; water / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

5: hydrogenchloride / diethyl ether; dichloromethane

6: Chiracel OJ column / methanol; carbon dioxide / Resolution of racemate

With hydrogenchloride; Chiracel OJ column; ammonia; hydrogen; N-ethyl-N,N-diisopropylamine; hydrazine; palladium 10% on activated carbon; nickel; In methanol; diethyl ether; ethanol; dichloromethane; carbon dioxide; water; N,N-dimethyl-formamide;

Reference yield:

: 1-(cis-3-propoxycyclohexyl)-4-piperidinamine

: 1067908-05-7
6-methyl-1-{1-[cis-3-(propyloxy)cyclohexyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one hydrochloride

: 1067908-07-9
6-methyl-1-{1-[cis-3-(propyloxy)cyclohexyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 200 °C / microwave reactor

2: hydrazine / nickel / ethanol; water / 2 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

4: hydrogenchloride / diethyl ether; dichloromethane

5: Chiracel OJ column / methanol; carbon dioxide / Resolution of racemate

With hydrogenchloride; Chiracel OJ column; N-ethyl-N,N-diisopropylamine; hydrazine; nickel; In methanol; diethyl ether; ethanol; dichloromethane; carbon dioxide; water; N,N-dimethyl-formamide;