(S)-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)(1-(hydroxymethyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone hydrochloride

Base Information

Chemical Name:(S)-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)(1-(hydroxymethyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone hydrochloride
CAS No.:1308338-81-9
Molecular Formula:C₂₉H₃₁FN₂O₄*ClH
Molecular Weight:527.035
Hs Code.:

(S)-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)(1-(hydroxymethyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone hydrochloride

Synonyms:(S)-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)(1-(hydroxymethyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone hydrochloride

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Chemical Property of (S)-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)(1-(hydroxymethyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone hydrochloride

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Technology Process of (S)-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)(1-(hydroxymethyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone hydrochloride

There total 8 articles about (S)-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)(1-(hydroxymethyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1308338-95-5
(S)-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)(1-(hydroxymethyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone

: 1308338-81-9
(S)-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)(1-(hydroxymethyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane;

Reference yield:

: 74163-81-8
L-Tic-OH

: 1308338-81-9
(S)-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)(1-(hydroxymethyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydrogencarbonate / 1,4-dioxane; water

2: dmap; diisopropyl-carbodiimide / dichloromethane / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.17 h / 120 °C / Microwave irradiation

4: trifluoroacetic acid / dichloromethane / 4 h

5: acetic acid; sodium tris(acetoxy)borohydride / N,N-dimethyl-formamide / 0.08 h / 100 °C / Microwave irradiation

6: hydrogenchloride / dichloromethane; diethyl ether

With hydrogenchloride; dmap; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; diisopropyl-carbodiimide; In 1,4-dioxane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 115962-35-1,144069-68-1,78879-20-6
(3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinole-3-carboxylic acid

: 1308338-81-9
(S)-(2-(2-fluorobenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)(1-(hydroxymethyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: dmap; diisopropyl-carbodiimide / dichloromethane / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.17 h / 120 °C / Microwave irradiation

3: trifluoroacetic acid / dichloromethane / 4 h

4: acetic acid; sodium tris(acetoxy)borohydride / N,N-dimethyl-formamide / 0.08 h / 100 °C / Microwave irradiation

5: hydrogenchloride / dichloromethane; diethyl ether

With hydrogenchloride; dmap; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; diisopropyl-carbodiimide; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;