N~2~-(5-cyclopropyl-1H-pyrazol-3-yl)-N~6~-[(1S)-1-(4-fluorophenyl)ethyl]-3-nitropyridine-2,6-diamine

Base Information

• Chemical Name: N~2~-(5-cyclopropyl-1H-pyrazol-3-yl)-N~6~-[(1S)-1-(4-fluorophenyl)ethyl]-3-nitropyridine-2,6-diamine
• CAS No.: 905586-06-3
• Molecular Formula: C₁₉H₁₉FN₆O₂
• Molecular Weight: 382.397
• Mol file: 905586-06-3.mol

Synonyms:(S)-N₂-(5-cyclopropyl-1H-pyrazol-3-yl)-N₆-(1-(4-fluoro-phenyl)ethyl)-3-nitropyridine-2,6-diamine

Chemical Property of N~2~-(5-cyclopropyl-1H-pyrazol-3-yl)-N~6~-[(1S)-1-(4-fluorophenyl)ethyl]-3-nitropyridine-2,6-diamine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N~2~-(5-cyclopropyl-1H-pyrazol-3-yl)-N~6~-[(1S)-1-(4-fluorophenyl)ethyl]-3-nitropyridine-2,6-diamine

There total 1 articles about N~2~-(5-cyclopropyl-1H-pyrazol-3-yl)-N~6~-[(1S)-1-(4-fluorophenyl)ethyl]-3-nitropyridine-2,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)-3-nitropyridin-2-amine (685867-14-5) + (S)-1-(4-Fluoro-phenyl)-ethylamine (66399-30-2) → (S)-N2-(5-cyclopropyl-1H-pyrazol-3-yl)-N6-(1-(4-fluoro-phenyl)ethyl)-3-nitropyridine-2,6-diamine (905586-06-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 165 ℃; for 18h; In sealed tube;

Reference yield:

(S)-N2-(5-cyclopropyl-1H-pyrazol-3-yl)-N6-(1-(4-fluoro-phenyl)ethyl)-3-nitropyridine-2,6-diamine (905586-06-3) → (S)-N2-(5-cyclopropyl-1H-pyrazol-3-yl)-N6-(1-(4-fluoro-phenyl)ethyl)pyridine-2,3,6-triamine

Guidance literature:

(S)-N₂-(5-cyclopropyl-1H-pyrazol-3-yl)-N₆-(1-(4-fluoro-phenyl)ethyl)-3-nitropyridine-2,6-diamine; With water; ammonium chloride; zinc; In tetrahydrofuran; methanol; at 25 ℃; for 1h;

With ammonium acetate; In tetrahydrofuran; methanol; water; for 0.5h;

Reference yield:

(S)-N2-(5-cyclopropyl-1H-pyrazol-3-yl)-N6-(1-(4-fluoro-phenyl)ethyl)-3-nitropyridine-2,6-diamine (905586-06-3) → ethyl (S)-5-amino-6-(5-cyclopropyl-1H-pyrazol-3-ylamino)-2-[1-(4-fluorophenyl)ethylamino]pyrimidine-4-carboxylate (907203-76-3)

Guidance literature:

(S)-N₂-(5-cyclopropyl-1H-pyrazol-3-yl)-N₆-(1-(4-fluoro-phenyl)ethyl)-3-nitropyridine-2,6-diamine; With ammonium chloride; zinc; In tetrahydrofuran; methanol; water; at 25 ℃; for 1h;

With ammonium acetate; In tetrahydrofuran; methanol; water; at 25 ℃; for 0.5h;

upstream raw materials:

6-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)-3-nitropyridin-2-amine

(S)-1-(4-Fluoro-phenyl)-ethylamine

Downstream raw materials:

ethyl (S)-5-amino-6-(5-cyclopropyl-1H-pyrazol-3-ylamino)-2-[1-(4-fluorophenyl)ethylamino]pyrimidine-4-carboxylate