(2S,3S,4S)-4-Benzyloxyamino-4-methyl-2-triisopropylsilanyloxy-hept-6-en-3-ol

Base Information

Chemical Name:(2S,3S,4S)-4-Benzyloxyamino-4-methyl-2-triisopropylsilanyloxy-hept-6-en-3-ol
CAS No.:213681-52-8
Molecular Formula:C₂₄H₄₃NO₃Si
Molecular Weight:421.696
Hs Code.:

Synonyms:(2S,3S,4S)-4-Benzyloxyamino-4-methyl-2-triisopropylsilanyloxy-hept-6-en-3-ol

Suppliers and Price of (2S,3S,4S)-4-Benzyloxyamino-4-methyl-2-triisopropylsilanyloxy-hept-6-en-3-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S,4S)-4-Benzyloxyamino-4-methyl-2-triisopropylsilanyloxy-hept-6-en-3-ol

Chemical Property:

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Technology Process of (2S,3S,4S)-4-Benzyloxyamino-4-methyl-2-triisopropylsilanyloxy-hept-6-en-3-ol

There total 7 articles about (2S,3S,4S)-4-Benzyloxyamino-4-methyl-2-triisopropylsilanyloxy-hept-6-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 250273-68-8
(2S,4S)-4-Benzyloxyamino-4-methyl-2-triisopropylsilanyloxy-hept-6-en-3-one

: 213681-44-8
(2S,3R,4S)-4-Benzyloxyamino-4-methyl-2-triisopropylsilanyloxy-hept-6-en-3-ol

: 213681-52-8
(2S,3S,4S)-4-Benzyloxyamino-4-methyl-2-triisopropylsilanyloxy-hept-6-en-3-ol

Guidance literature:: With sodium tetrahydroborate; In methanol; diethyl ether; at 0 ℃; for 2h; Yield given. Yields of byproduct given;
DOI:10.1002/(SICI)1521-3773(19980803)37:13/14<1871::AID-ANIE1871>3.0.CO;2-1

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 213681-52-8
(2S,3S,4S)-4-Benzyloxyamino-4-methyl-2-triisopropylsilanyloxy-hept-6-en-3-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / imidazole / dimethylformamide / 10 h

2: DIBAL / CH₂Cl₂ / 0.75 h / -78 °C

3: 2.) HCl, H₂O / 1.) THF, -100 degC, 2.) THF

4: 97 percent / pyridine / 0 - 25 °C

5: diethyl ether / -35 °C

6: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) -78 deg C, 2.) -78 to 0 deg C

7: NaBH₄ / diethyl ether; methanol / 2 h / 0 °C

With pyridine; 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; water; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/(SICI)1521-3773(19980803)37:13/14<1871::AID-ANIE1871>3.0.CO;2-1

Reference yield:

: 135614-60-7
(2S)-2-(triisopropylsilyloxy)propionaldehyde

: 213681-52-8
(2S,3S,4S)-4-Benzyloxyamino-4-methyl-2-triisopropylsilanyloxy-hept-6-en-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 2.) HCl, H₂O / 1.) THF, -100 degC, 2.) THF

2: 97 percent / pyridine / 0 - 25 °C

3: diethyl ether / -35 °C

4: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) -78 deg C, 2.) -78 to 0 deg C

5: NaBH₄ / diethyl ether; methanol / 2 h / 0 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; water; dimethyl sulfoxide; triethylamine; In methanol; diethyl ether;
DOI:10.1002/(SICI)1521-3773(19980803)37:13/14<1871::AID-ANIE1871>3.0.CO;2-1