N-<<(2-amino-4-hydroxy-7,8-dihydro-8-oxa-6-pteridinyl)methyl>benzoyl>-L-glutamate

Base Information

Chemical Name:N-<<(2-amino-4-hydroxy-7,8-dihydro-8-oxa-6-pteridinyl)methyl>benzoyl>-L-glutamate
CAS No.:85828-44-0
Molecular Formula:C₁₉H₁₉N₅O₇
Molecular Weight:429.389
Hs Code.:

Synonyms:N-<<(2-amino-4-hydroxy-7,8-dihydro-8-oxa-6-pteridinyl)methyl>benzoyl>-L-glutamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<<(2-amino-4-hydroxy-7,8-dihydro-8-oxa-6-pteridinyl)methyl>benzoyl>-L-glutamate

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Technology Process of N-<<(2-amino-4-hydroxy-7,8-dihydro-8-oxa-6-pteridinyl)methyl>benzoyl>-L-glutamate

There total 10 articles about N-<<(2-amino-4-hydroxy-7,8-dihydro-8-oxa-6-pteridinyl)methyl>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85828-54-2
diethyl N-<<(2-amino-4-hydroxy-7,8-dihydro-8-oxa-6-pteridinyl)methyl>benzoyl>-L-glutamate

: 85828-44-0
N-<<(2-amino-4-hydroxy-7,8-dihydro-8-oxa-6-pteridinyl)methyl>benzoyl>-L-glutamate

: 85828-55-3
N-<<(2-amino-4-hydroxy-7,8-dihydro-8-oxa-6-ptaridinyl)methenyl>benzoyl>-L-glutamate

Guidance literature:: With sodium hydroxide; In acetonitrile; at 25 ℃; for 6h;
DOI:10.1021/jm00362a015

Reference yield:

: 1075-49-6
4-ethenylbenzoic acid

: 85828-44-0
N-<<(2-amino-4-hydroxy-7,8-dihydro-8-oxa-6-pteridinyl)methyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) DMF, 15 min, 2.) DMF, 25 deg C, 18 h

2: m-chloroperbenzoic acid / CHCl₃ / 72 h / 25 °C

3: 75 percent / HBr / CH₂Cl₂ / 0.33 h

4: 92.6 percent / Jones reagent / acetone / 0.33 h

5: 96 percent / HOAc, Zn / 1 h

6: SOCl₂ / benzene / 1.5 h / Heating

7: 1.) SOCl₂, 3.) HBr

8: 30 percent / magnesium oxide / methanol / 3 h / Heating

9: 120 mg / 0.1N aq NaOH / acetonitrile / 6 h / 25 °C

With 4-methyl-morpholine; sodium hydroxide; thionyl chloride; jones reagent; hydrogen bromide; magnesium oxide; acetic acid; 3-chloro-benzenecarboperoxoic acid; zinc; isobutyl chloroformate; In methanol; dichloromethane; chloroform; acetone; acetonitrile; benzene;
DOI:10.1021/jm00362a015

Reference yield:

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 85828-44-0
N-<<(2-amino-4-hydroxy-7,8-dihydro-8-oxa-6-pteridinyl)methyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) DMF, 15 min, 2.) DMF, 25 deg C, 18 h

2: m-chloroperbenzoic acid / CHCl₃ / 72 h / 25 °C

3: 75 percent / HBr / CH₂Cl₂ / 0.33 h

4: 92.6 percent / Jones reagent / acetone / 0.33 h

5: 96 percent / HOAc, Zn / 1 h

6: SOCl₂ / benzene / 1.5 h / Heating

7: 1.) SOCl₂, 3.) HBr

8: 30 percent / magnesium oxide / methanol / 3 h / Heating

9: 120 mg / 0.1N aq NaOH / acetonitrile / 6 h / 25 °C

With 4-methyl-morpholine; sodium hydroxide; thionyl chloride; jones reagent; hydrogen bromide; magnesium oxide; acetic acid; 3-chloro-benzenecarboperoxoic acid; zinc; isobutyl chloroformate; In methanol; dichloromethane; chloroform; acetone; acetonitrile; benzene;
DOI:10.1021/jm00362a015