benzyl (1S,2R)-2-[(1S)-1-[(1-oxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-1,2,3,4-tetrahydro isoquinoline-2-carbonyl]cyclohexane-1-carboxylate

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Chemical Name:benzyl (1S,2R)-2-[(1S)-1-[(1-oxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-1,2,3,4-tetrahydro isoquinoline-2-carbonyl]cyclohexane-1-carboxylate
CAS No.:1607007-40-8
Molecular Formula:C₃₃H₃₄N₂O₄
Molecular Weight:522.644
Hs Code.:

Synonyms:benzyl (1S,2R)-2-[(1S)-1-[(1-oxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-1,2,3,4-tetrahydro isoquinoline-2-carbonyl]cyclohexane-1-carboxylate

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Chemical Property of benzyl (1S,2R)-2-[(1S)-1-[(1-oxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-1,2,3,4-tetrahydro isoquinoline-2-carbonyl]cyclohexane-1-carboxylate

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Technology Process of benzyl (1S,2R)-2-[(1S)-1-[(1-oxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-1,2,3,4-tetrahydro isoquinoline-2-carbonyl]cyclohexane-1-carboxylate

There total 11 articles about benzyl (1S,2R)-2-[(1S)-1-[(1-oxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-1,2,3,4-tetrahydro isoquinoline-2-carbonyl]cyclohexane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1607007-35-1
2-[(1S)-1,2,3,4-tetrahydroisoquinolin-1-ylmethyl]-2,3-dihydro-1H-isoindol-1-one

: 151434-99-0
(1R,2S)-cis-2-benzyloxycarbonyl-cyclohexane-1-carboxylic acid

: 1607007-40-8
benzyl (1S,2R)-2-[(1S)-1-[(1-oxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-1,2,3,4-tetrahydro isoquinoline-2-carbonyl]cyclohexane-1-carboxylate

Guidance literature:: (1R,2S)-cis-2-benzyloxycarbonyl-cyclohexane-1-carboxylic acid; With thionyl chloride; In dichloromethane; at 20 ℃; for 4h;

2-[(1S)-1,2,3,4-tetrahydroisoquinolin-1-ylmethyl]-2,3-dihydro-1H-isoindol-1-one; With pyridine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1002/cmdc.201300525

Reference yield:

: 1607007-21-5
(S)-1,5,6,10b-tetrahydro-3H-oxazolo[4,3-a]isoquinolin-3-one

: 1607007-40-8
benzyl (1S,2R)-2-[(1S)-1-[(1-oxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-1,2,3,4-tetrahydro isoquinoline-2-carbonyl]cyclohexane-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / ethanol / 1 h / Reflux

2.1: 1H-imidazole; triethylamine; thionyl chloride / dichloromethane / 1 h / 0 °C

2.2: 1.5 h / 0 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 4 h / 20 °C

4.1: thionyl chloride / dichloromethane / 4 h / 20 °C

4.2: 16 h / 20 °C

With 1H-imidazole; thionyl chloride; sodium hydride; triethylamine; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201300525

Reference yield:

: 872986-64-6
(S)-(1,2,3,4-tetrahydroisoquinolin-1-yl)methanol

: 1607007-40-8
benzyl (1S,2R)-2-[(1S)-1-[(1-oxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-1,2,3,4-tetrahydro isoquinoline-2-carbonyl]cyclohexane-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole; triethylamine; thionyl chloride / dichloromethane / 1 h / 0 °C

1.2: 1.5 h / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 4 h / 20 °C

3.1: thionyl chloride / dichloromethane / 4 h / 20 °C

3.2: 16 h / 20 °C

With 1H-imidazole; thionyl chloride; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201300525