<3-(3-Methyl-2-thienyl)propenoyl(phenyl)methylene>triphenylphosphorane

Base Information

• Chemical Name: <3-(3-Methyl-2-thienyl)propenoyl(phenyl)methylene>triphenylphosphorane
• CAS No.: 167561-59-3
• Molecular Formula: C₃₃H₂₇OPS
• Molecular Weight: 502.617
• Mol file: 167561-59-3.mol

Synonyms:<3-(3-Methyl-2-thienyl)propenoyl(phenyl)methylene>triphenylphosphorane

Chemical Property of <3-(3-Methyl-2-thienyl)propenoyl(phenyl)methylene>triphenylphosphorane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <3-(3-Methyl-2-thienyl)propenoyl(phenyl)methylene>triphenylphosphorane

There total 5 articles about <3-(3-Methyl-2-thienyl)propenoyl(phenyl)methylene>triphenylphosphorane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

3-(3-Methyl-2-thienyl)propenoyl chloride (167561-45-7) + triphenyl(phenylmethylene)phosphorane (16721-45-2) → <3-(3-Methyl-2-thienyl)propenoyl(phenyl)methylene>triphenylphosphorane (167561-59-3)

Guidance literature:

DOI:10.1016/0040-4039(94)02445-H

Reference yield:

3-methyl-2-thiophenecarboxaldehdye (5834-16-2,699531-50-5) → <3-(3-Methyl-2-thienyl)propenoyl(phenyl)methylene>triphenylphosphorane (167561-59-3)

Guidance literature:

Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran

2: H₂O

3: SOCl₂ / 2 h / Heating

4: 1.) BuLi / 1.) THF, hexane, r.t., 15 min, 2.) 8 h

With n-butyllithium; thionyl chloride; water; sodium hydride; In tetrahydrofuran;

Reference yield:

(E)-3-(3-methyl-thien-2-yl)-2-propenoic acid (102696-70-8,77741-66-3) → <3-(3-Methyl-2-thienyl)propenoyl(phenyl)methylene>triphenylphosphorane (167561-59-3)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 2 h / Heating

2: 1.) BuLi / 1.) THF, hexane, r.t., 15 min, 2.) 8 h

With n-butyllithium; thionyl chloride;

upstream raw materials:

3-(3-Methyl-2-thienyl)propenoyl chloride

triphenyl(phenylmethylene)phosphorane

benzyltriphenylphosphonium bromide

3-methyl-2-thiophenecarboxaldehdye

Downstream raw materials:

Triphenylphosphine oxide