9-OXO-11ALPHA,16R-DIHYDROXY-17-CYCLOBUTYL-5Z,13E-DIEN-1-OIC ACID

Base Information

Chemical Name:9-OXO-11ALPHA,16R-DIHYDROXY-17-CYCLOBUTYL-5Z,13E-DIEN-1-OIC ACID
CAS No.:212310-16-2
Molecular Formula:C₂₃H₃₆O₅
Molecular Weight:392.536
Hs Code.:
Mol file:212310-16-2.mol

Synonyms:5-Heptenoicacid,7-[(1R,2R,3R)-3-hydroxy-2-[(1E,4R)-4-hydroxy-4-(1-propylcyclobutyl)-1-butenyl]-5-oxocyclopentyl]-,(5Z)- (9CI)

Suppliers and Price of 9-OXO-11ALPHA,16R-DIHYDROXY-17-CYCLOBUTYL-5Z,13E-DIEN-1-OIC ACID

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
CAY10408 ≥98%
5mg
$ 594.00

Cayman Chemical
CAY10408 ≥98%
1mg
$ 133.00

Cayman Chemical
CAY10408 ≥98%
10mg
$ 1055.00

AK Scientific
9-oxo-11alpha,16R-Dihydroxy-17-cyclobutyl-5Z,13E-dien-1-oicacid
5mg
$ 841.00

Total 5 raw suppliers

Chemical Property of 9-OXO-11ALPHA,16R-DIHYDROXY-17-CYCLOBUTYL-5Z,13E-DIEN-1-OIC ACID

Chemical Property:

PSA：94.83000
LogP:4.03130

Purity/Quality:

99% ^*data from raw suppliers

CAY10408 ≥98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 9-OXO-11ALPHA,16R-DIHYDROXY-17-CYCLOBUTYL-5Z,13E-DIEN-1-OIC ACID

There total 19 articles about 9-OXO-11ALPHA,16R-DIHYDROXY-17-CYCLOBUTYL-5Z,13E-DIEN-1-OIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 212309-91-6
(Z)-7-{(1R,2R,3R)-3-Hydroxy-2-[(E)-(S)-4-hydroxy-4-(1-propyl-cyclobutyl)-but-1-enyl]-5-oxo-cyclopentyl}-hept-5-enoic acid methyl ester

: 212310-16-2
CAY10399

Guidance literature:: With porcine liver esterase; ammonium sulfate; In phosphate buffer; ethanol; at 20 ℃; for 6h; pH=7.4;
DOI:10.1016/S0968-0896(01)00369-8

Reference yield:

: 212309-90-5
(Z)-7-{(1R,2R,3R)-3-Hydroxy-2-[(E)-(R)-4-hydroxy-4-(1-propyl-cyclobutyl)-but-1-enyl]-5-oxo-cyclopentyl}-hept-5-enoic acid methyl ester

: 212310-16-2
CAY10408

Guidance literature:: With porcine liver esterase; ammonium sulfate; In phosphate buffer; ethanol; at 20 ℃; for 6h; pH=7.4;
DOI:10.1016/S0968-0896(01)00369-8

Reference yield:

: 3721-95-7
Cyclobutanecarboxylic acid

: 212310-16-2
CAY10408

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium diisopropylamide / tetrahydrofuran / 12 h / 20 °C

2.1: 100 percent / LiAlH₄ / diethyl ether / 3.5 h / 20 °C

3.1: 59 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 1.5 h / -78 - 0 °C

4.1: Mg; mercuric chloride / diethyl ether / 0.17 h / 0 °C

4.2: 85 percent / diethyl ether / 1 h / 20 °C

5.1: 94 percent / 2,6-lutidine / CH₂Cl₂ / 0.17 h / 0 - 20 °C

6.1: Cp₂ZrClH / tetrahydrofuran / 0.5 h / 20 °C

6.2: 86 percent / I₂ / tetrahydrofuran / 0.17 h / 20 °C

7.1: 66 percent / t-BuLi; lithium 2-thienylcyanocuprate / diethyl ether; pentane; tetrahydrofuran / 1 h / -78 - 0 °C

8.1: 48 percent / aq. HF / acetonitrile / 1.5 h / 20 °C

9.1: porcine liver esterase; aq. ammonium sulfate / ethanol; aq. phosphate buffer / 6 h / 20 °C / pH 7.4

With 2,6-dimethylpyridine; porcine liver esterase; ammonium sulfate; lithium aluminium tetrahydride; Schwartz's reagent; oxalyl dichloride; hydrogen fluoride; tert.-butyl lithium; magnesium; dimethyl sulfoxide; thien-2-yl(cyano)copper lithium; triethylamine; mercury dichloride; lithium diisopropyl amide; In tetrahydrofuran; phosphate buffer; diethyl ether; ethanol; dichloromethane; acetonitrile; pentane; 3.1: Swern oxidation;
DOI:10.1016/S0968-0896(01)00369-8