N-cyclododecyl-2-(4-(1-diazoethyl)-2-methoxy-5-nitrophenoxy)acetamide

Base Information

• Chemical Name: N-cyclododecyl-2-(4-(1-diazoethyl)-2-methoxy-5-nitrophenoxy)acetamide
• CAS No.: 1262298-75-8
• Molecular Formula: C₂₃H₃₄N₄O₅
• Molecular Weight: 446.547
• Mol file: 1262298-75-8.mol

Synonyms:N-cyclododecyl-2-(4-(1-diazoethyl)-2-methoxy-5-nitrophenoxy)acetamide

Chemical Property of N-cyclododecyl-2-(4-(1-diazoethyl)-2-methoxy-5-nitrophenoxy)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-cyclododecyl-2-(4-(1-diazoethyl)-2-methoxy-5-nitrophenoxy)acetamide

There total 4 articles about N-cyclododecyl-2-(4-(1-diazoethyl)-2-methoxy-5-nitrophenoxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E/Z)-N-cyclododecyl-2-(4-(1-hydrazonoethyl)-2-methoxy-5-nitrophenoxy)acetamide (1262298-74-7) → N-cyclododecyl-2-(4-(1-diazoethyl)-2-methoxy-5-nitrophenoxy)acetamide (1262298-75-8)

Guidance literature:

With manganese(IV) oxide; In dimethyl sulfoxide; at 20 ℃; for 0.833333h; Darkness;

DOI:10.1021/ja107226e

Reference yield:

(4-acetyl-2-methoxy-phenoxy)acetic acid tert-butyl ester (188891-12-5) → N-cyclododecyl-2-(4-(1-diazoethyl)-2-methoxy-5-nitrophenoxy)acetamide (1262298-75-8)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic anhydride; nitric acid / 6 h / 20 °C / Cooling with ice

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 15 h

3: hydrazine hydrate; acetic acid / acetonitrile; ethanol / 4 h / 90 °C / Sealed tube

4: manganese(IV) oxide / dimethyl sulfoxide / 0.75 h

With manganese(IV) oxide; nitric acid; acetic anhydride; benzotriazol-1-ol; hydrazine hydrate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

1-(3-methoxy-4-hydroxyphenyl)ethanone (498-02-2) → N-cyclododecyl-2-(4-(1-diazoethyl)-2-methoxy-5-nitrophenoxy)acetamide (1262298-75-8)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

2: acetic anhydride; nitric acid / 6 h / 20 °C / Cooling with ice

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 15 h

4: hydrazine hydrate; acetic acid / acetonitrile; ethanol / 4 h / 90 °C / Sealed tube

5: manganese(IV) oxide / dimethyl sulfoxide / 0.75 h

With manganese(IV) oxide; nitric acid; acetic anhydride; potassium carbonate; benzotriazol-1-ol; hydrazine hydrate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

(E/Z)-N-cyclododecyl-2-(4-(1-hydrazonoethyl)-2-methoxy-5-nitrophenoxy)acetamide

1-(3-methoxy-4-hydroxyphenyl)ethanone

(4-acetyl-2-methoxy-phenoxy)acetic acid tert-butyl ester

2-(4-acetyl-2-methoxy-5-nitrophenoxy)acetic acid