3-[(tert-butoxycarbonyl)amino]-2-[4-[[(triisopropylsilyl)oxy]methyl]phenyl]propionic acid

Base Information

Chemical Name:3-[(tert-butoxycarbonyl)amino]-2-[4-[[(triisopropylsilyl)oxy]methyl]phenyl]propionic acid
CAS No.:1253955-24-6
Molecular Formula:C₂₄H₄₁NO₅Si
Molecular Weight:451.679
Hs Code.:

Synonyms:3-[(tert-butoxycarbonyl)amino]-2-[4-[[(triisopropylsilyl)oxy]methyl]phenyl]propionic acid

Suppliers and Price of 3-[(tert-butoxycarbonyl)amino]-2-[4-[[(triisopropylsilyl)oxy]methyl]phenyl]propionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 3-[(tert-butoxycarbonyl)amino]-2-[4-[[(triisopropylsilyl)oxy]methyl]phenyl]propionic acid

Chemical Property:

Boiling Point:539.6±50.0 °C(Predicted)
Density:1.033±0.06 g/cm3(Predicted)

Purity/Quality:: 98.0% ^*data from raw suppliers

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Technology Process of 3-[(tert-butoxycarbonyl)amino]-2-[4-[[(triisopropylsilyl)oxy]methyl]phenyl]propionic acid

There total 18 articles about 3-[(tert-butoxycarbonyl)amino]-2-[4-[[(triisopropylsilyl)oxy]methyl]phenyl]propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1253955-57-5
methyl 3-((tert-butoxycarbonyl)amino)-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)propanoate

: 1253955-24-6
3-[(tert-butoxycarbonyl)amino]-2-[4-[[(triisopropylsilyl)oxy]methyl]phenyl]propionic acid

Guidance literature:: With methanol; water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 1253955-24-6
3-[(tert-butoxycarbonyl)amino]-2-[4-[[(triisopropylsilyl)oxy]methyl]phenyl]propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 1H-imidazole / dichloromethane / 20 °C

2: sulfuric acid / 2 h / Reflux

3: triethylamine / 20 °C / Inert atmosphere

4: triethylamine; methanesulfonyl chloride / dichloromethane / 10 - 20 °C / Inert atmosphere

5: sodium tetrahydroborate; methanol / dichloromethane / 0 - 5 °C / Inert atmosphere

6: hydrogen / methanol / 40 °C

7: triethylamine / dichloromethane / 1 h / 0 - 10 °C

8: sodium hydroxide; water / methanol / 3 h / 20 °C

With 1H-imidazole; methanol; sodium tetrahydroborate; sulfuric acid; water; hydrogen; methanesulfonyl chloride; triethylamine; sodium hydroxide; In methanol; dichloromethane; 3: |Henry Nitro Aldol Condensation;

Reference yield:

: C₂₀H₃₁NO₅Si

: 1253955-24-6
3-[(tert-butoxycarbonyl)amino]-2-[4-[[(triisopropylsilyl)oxy]methyl]phenyl]propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate; methanol / dichloromethane / 0 - 5 °C / Inert atmosphere

2: hydrogen / methanol / 40 °C

3: triethylamine / dichloromethane / 1 h / 0 - 10 °C

4: sodium hydroxide; water / methanol / 3 h / 20 °C

With methanol; sodium tetrahydroborate; water; hydrogen; triethylamine; sodium hydroxide; In methanol; dichloromethane;