(2R,6S)-6-[(4S)-4-benzyloxy-3,3-dimethyl-2-oxohex-5-enyl]-2-[(tert-butyldiphenylsilyloxy)methyl]-4-methyl-4,1''-epoxytetrahydropyran

Base Information

Chemical Name:(2R,6S)-6-[(4S)-4-benzyloxy-3,3-dimethyl-2-oxohex-5-enyl]-2-[(tert-butyldiphenylsilyloxy)methyl]-4-methyl-4,1''-epoxytetrahydropyran
CAS No.:1314809-11-4
Molecular Formula:C₃₈H₄₈O₅Si
Molecular Weight:612.882
Hs Code.:

Synonyms:(2R,6S)-6-[(4S)-4-benzyloxy-3,3-dimethyl-2-oxohex-5-enyl]-2-[(tert-butyldiphenylsilyloxy)methyl]-4-methyl-4,1''-epoxytetrahydropyran

Suppliers and Price of (2R,6S)-6-[(4S)-4-benzyloxy-3,3-dimethyl-2-oxohex-5-enyl]-2-[(tert-butyldiphenylsilyloxy)methyl]-4-methyl-4,1''-epoxytetrahydropyran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,6S)-6-[(4S)-4-benzyloxy-3,3-dimethyl-2-oxohex-5-enyl]-2-[(tert-butyldiphenylsilyloxy)methyl]-4-methyl-4,1''-epoxytetrahydropyran

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,6S)-6-[(4S)-4-benzyloxy-3,3-dimethyl-2-oxohex-5-enyl]-2-[(tert-butyldiphenylsilyloxy)methyl]-4-methyl-4,1''-epoxytetrahydropyran

There total 11 articles about (2R,6S)-6-[(4S)-4-benzyloxy-3,3-dimethyl-2-oxohex-5-enyl]-2-[(tert-butyldiphenylsilyloxy)methyl]-4-methyl-4,1''-epoxytetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1314809-09-0
(2R,6S)-6-[(4S)-4-benzyloxy-3,3-dimethyl-2-oxohex-5-enyl]-2-[(tert-butyldiphenylsilyloxy)methyl]-4-methylenetetrahydropyran

: 1314809-11-4
(2R,6S)-6-[(4S)-4-benzyloxy-3,3-dimethyl-2-oxohex-5-enyl]-2-[(tert-butyldiphenylsilyloxy)methyl]-4-methyl-4,1''-epoxytetrahydropyran

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 5h; Inert atmosphere;
DOI:10.1016/j.tet.2011.03.113

Reference yield:

: 1314808-90-6
(R)-1-[(2-trimethylsilylethoxy)methoxy]-4-(trimethylsilylmethyl)pent-4-en-2-ol

: 1314809-11-4
(2R,6S)-6-[(4S)-4-benzyloxy-3,3-dimethyl-2-oxohex-5-enyl]-2-[(tert-butyldiphenylsilyloxy)methyl]-4-methyl-4,1''-epoxytetrahydropyran

Guidance literature:: Multi-step reaction with 5 steps

1: 2,6-dimethylpyridine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

2: zinc(II) iodide / dichloromethane / 24 h / 20 °C / Inert atmosphere; Molecular sieve; Darkness

3: hydrogen fluoride; water / acetonitrile / 18 h / 20 °C

4: 1H-imidazole / dichloromethane / 18 h / 20 °C / Inert atmosphere

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 0 °C / Inert atmosphere

With 1H-imidazole; 2,6-dimethylpyridine; hydrogen fluoride; water; 3-chloro-benzenecarboperoxoic acid; zinc(II) iodide; In dichloromethane; acetonitrile; 3: oxy-Michael reaction;
DOI:10.1016/j.tet.2011.03.113

Reference yield:

: 1314808-96-2
(3RS,5S)-5-benzyloxy-4,4-dimethylhept-6-en-1-yn-3-ol

: 1314809-11-4
(2R,6S)-6-[(4S)-4-benzyloxy-3,3-dimethyl-2-oxohex-5-enyl]-2-[(tert-butyldiphenylsilyloxy)methyl]-4-methyl-4,1''-epoxytetrahydropyran

Guidance literature:: Multi-step reaction with 5 steps

1: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2: zinc(II) iodide / dichloromethane / 24 h / 20 °C / Inert atmosphere; Molecular sieve; Darkness

3: hydrogen fluoride; water / acetonitrile / 18 h / 20 °C

4: 1H-imidazole / dichloromethane / 18 h / 20 °C / Inert atmosphere

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 0 °C / Inert atmosphere

With 1H-imidazole; hydrogen fluoride; water; Dess-Martin periodane; 3-chloro-benzenecarboperoxoic acid; zinc(II) iodide; In dichloromethane; acetonitrile; 3: oxy-Michael reaction;
DOI:10.1016/j.tet.2011.03.113